Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar

Eniko Kiszelly

Lujza E Petocz

Ibolya Kosoczky

Katalin Grasser

Jozsef Nagy

Laszlo Rozsa

Tibor Mezei

Zoltan Budai

Marton Fekete

Attila Mandi

Gabor Gigler

Frigyes Gorgenyi

Aranka Lay Nee Konya

Istvan Simonyi

Ivan Beck

Andras Dietz

Laszlo Magdanyi

Elemer Jakfalvi

Attila Varga

Katalin Sumeg Nee Zukovics

The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.

Pharmaceutical composition

The invention relates to novel cyclododecane derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 represent independently from each other a hydrogen atom, a C.sub.1-6 alkyl group or a C.sub.3-8 cycloalkyl group, or R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached a heterocyclic ring containing 4 to 7 carbon atoms and optionally a further heteroatom selected from the group consisting of oxygen, sulphur and nitrogen, said ring may be optionally substituted by a C.sub.1-3 alkyl or benzyl group; and A represents a C.sub.2-6 straight or branched alkylene chain, and optically active isomers, acid addition salts and quaternary ammonium derivatives thereof. The invention relates further to an analogous process for the preparation of said compounds, to pharmaceutical compositions containing said compounds as the active ingredient and to a process for the preparation of said pharmaceutical compositions. The cyclododecane derivatives of the invention possess valuable biological properties.

Cyclododecanone oximes

This invention relates to novel dibenzo[d,g][1,3,6]dioxazocine derivatives represented by the general formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, cyano or trifluoromethyl,

Dibenzo[d,g][1,3,6]dioxazocine derivatives

New compounds of the general formula (I) ##SPC1## and salts thereof were prepared by reacting a compound of the general formula (II) ##SPC2## with a compound of the general formula (III) or (IV) ##EQU1## and optionally saturating the --C=N-- bond. In the above formulae

Indazole-3-carboxylic acid hydrazides and a process for the preparation

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Budapest, Hungary

Eniko Kiszelly