Pts Corporation

Altera Corporation

Verseon Corporation

Other

Pulsent Corporation

Eniko Fodor

Adityo Prakash

David B Kita

Edward R Ratner

Somalee Datta

David L Cook

Sachin Ahuja

David Cook

The present invention includes various embodiments of a BSA system that facilitates the collection of relevant health-related data on a continuous basis, integrates such data with pertinent personal and aggregate information, enables users to purchase (directly and indirectly) health-related goods and services, and provides credit, discounts and other economic benefits in connection with such purchases that are determined dynamically based upon the nature and extent of users' interaction with the system. The BSA system facilitates a dynamic feedback process by continually monitoring user interaction and medical and financial behavior, which results in dynamic adjustments to their credit levels and offers of discounts and other promotions, which in turn incentivizes users to continue participating in the process (thereby modifying their system interactions and behavior, and thus perpetuating this feedback loop). As a result, users are incentivized to actively participate in the process and thereby enhance their wellness while reducing healthcare costs.

Facilitating integrated behavioral support through personalized adaptive data collection

Systems and methods for facilitating integrated behavioral support

An encoder segments frames of video data and associates metadata with segments. The metadata elements can be associated with the segments that include areas of the frame associated with the metadata elements. A motion matcher can match segments of a reference frame to pixels of a current nonkey frame being encoded when a metadata associator associates elements of metadata with segments of the segmentation of the reference frame and associates a matched segment's metadata elements with matched areas of the current frame. The metadata elements might represent actions to be taken when a user of the video data indicates a selection of an area of an image that has that metadata element associated therewith. The metadata associations can be included in the encoded video data or deduced by a decoder. The metadata associations can be independent of segment indices or other segment changes.

Segment-based encoding system including segment-specific metadata

A method for partitioning a molecular subset is described. The partitioning method takes into account molecular structure and its manner of storage and transmission, transformations to be applied to the molecular subset and their implementation, and constraints imposed by the implementation of the partitioning method. Using this method, a molecular subset can be stored, transmitted, and processed more efficiently. The resulting efficiency makes it possible to design and run applications which require complex molecular processing, such as rational drug discovery, virtual library design, etc.

Method and device for partitioning a molecule

An encoding system includes an encoder that encodes uncompressed video data to form compressed video data and a decoder that decodes the compressed video data to form at least an approximation of the uncompressed video data. The video data comprises a sequence of a plurality of image frames comprising key frames and nonkey frames. In encoding a nonkey frame, reference is made to segments of a reference frame. Kinetic information, such as motion vectors, relates portions of the nonkey frame to the segments of it reference frame. The information content of the nonkey frame that is not conveyed by the segmentation, the reference frame content and the kinetic information can be encoded as residue data. Each segment's residue data, or the nonkey frame's residue data, can be encoded as coefficients of basis functions known to both the encoder and the decoder.

Segment-based encoding system using residue coding by basis function coefficients

Computing units are determined for performing molecular docking calculations in parallel with the number of computing units and the width of the data paths allocated by relative complexity of operations. Data can be expected to arrive at downstream computing units as it is needed, leading to higher utilization of computing units. Computing units are hardware components that are specific to a calculation performed. For molecular docking calculations, functions of molecular subsets or of combinations of molecular subsets are calculated. Determinations include fit between molecular subsets, affinity or energy of 'fit' between molecular subsets, etc. Affinity might include inter-atomic energy, bond energy, energy of atoms immersed in a field, etc. The calculations could be used to simulate and/or estimate likelihoods of molecular interactions.

Method and apparatus for analysis of molecular configurations and combinations

A method and apparatus for analysis of molecular combinations featuring two or more molecular subsets is described. The method computes the shape complementarity of the system utilizing a basis expansion representing molecular shapes of the first and second molecular subsets in a coordinate system. The precomputed sets of translated expansion coefficients for the first molecular subset are first constructed via application of a translation operator to a reference set of expansion coefficients and then stored on a computer recordable medium for later retrieval. Then, a shape complementarity score, representing a correlation of the first and second molecular subsets, is computed via suitable application of rotation operators to both the stored translated expansion coefficients of the first molecular subset and the reference expansion coefficients for the second molecular subset over the sequence of different sampled configurations for the molecular combination.

Method and apparatus for analysis of molecular combination based on computations of shape complementarity using basis expansions

A method for the prediction of adverse cross-reactions between lead candidate biomolecules and potential reactant molecules, often biopolymers, is described. In a computational system, reactions are modeled within a suitable environment, in order to determine a reaction profile between a lead candidate molecule and a potential reactant molecule. A risk assessment is then generated for each lead based on a plurality of reaction profiles for the lead with respect to a plurality of potential reactant molecules. The method includes provisions for redesign and optimization of the lead candidate, possibly iterative in nature, in order to avoid predicted adverse cross-reactions.

Lead molecule cross-reaction prediction and optimization system

In one embodiment according to the present invention, relative z-ordering of segments in a digital image is determined. A method comprises forward and backward motion matching of image regions to determine overlap, followed by the creation of relationships (e.g., pairwise relationships) between regions and comparing the result with the original image to determine the relative z-ordering.

Method of determining relative z-ordering in an image and method of using same

Motion vectors encode for differences between segments of a reference frame and pixels of a current frame being encoded when the current frame is a nonkey frame. The motion vectors are encoded by grouping one or more segments of the frame into a group of segments, generating a group motion vector for the group of segments and one or more local motion vectors, wherein a local motion vector corresponds to a segment in the one or more segments and specifies a change for the segment relative to the motion vector for the group of segments and encoding the motion vector and one or more local motion vectors. The group motion vector can be determined based on a relationship between the motion vectors for the one or more segments. The grouping can be hierarchical. The motion vectors can represent translation, z-ordering, deformation, and/or lighting data.

Encoding system using motion vectors to represent frame-to-frame changes, including motion vector grouping for coding or processing

Video data is encoded to form compressed video data wherein at least some of the frames are encoded as nonkey frames with reference to content of reference frames. In encoding a nonkey frame, segments of a reference frame can be matched to the pixels of the nonkey frame and related by a calculated motion vector for each segment, wherein a motion vector represents a difference in position of the image area represented by the segment. Motion vectors are predicted and the encoding of the nonkey frame can omit coding for calculated motion vectors that are sufficiently close to their predicted values and encoding differences between calculated and predicted motion vectors. Differences in values can be considered residue and coded as part of residue data. A decoder making similar predictions can decode the compressed video data even when the compressed video data contains no information about the predictions for motion vectors.

Encoding system using motion vectors to represent frame-to-frame changes, wherein a decoder uses predictions of motion vectors in decoding

An encoding system encodes and decodes video data using an exposed area fill processor. A nonkey frame is encoded as a set of kinetic information relating segments of a reference frame to the nonkey frame and the nonkey frame is decoded from segments of at least one reference frame, the kinetic information and results of an exposed area fill process that estimates contents of the nonkey frame not already covered by the segments and the kinetic information. The exposed area fill results can be determined at the encoder and conveyed to the decoder or the decoder can determine the results independently. The encoded video data can include an indication of which of a plurality of fill schemes are used, or the decoder can determine the indication by itself. The exposed area fill information might include bounds of areas to be filled and/or pixel values of pixels therein.

Segment-based encoding system using exposed area filling performed by an encoder and a decoder

Video data is compressed with nonkey frames encoded with reference to segmentation of reference frames, where the encoded video data includes kinetic information relating segments of a reference frame to pixels of a nonkey frame and the kinetic information includes translations of segments and at least one of a z-order, a deformation and a lighting change. The segmentation performed during encoding can be included in whole or part in the compressed video data. If used, z-ordering could be relative or absolute, based on changes of occlusion of segments by other segments between the frames, based on content of other frames or based on z-order indications in the video data being compressed. Other kinetic information might include segment changes between frames such as rotation, dilation, affine transformations, nonlinear transformations defined by a set of deformation parameters, linear lighting offsets in one, two or three color planes, and/or residue information.

Segmenting encoding system encoding video data using segment-by-segment kinetic data including change information in addition to translation information

Video data is compressed using segmentation of reference frames where the segmentation results in a hierarchy of segments. The hierarchy can be generated bottom-up, where a first set of segments is generated and then a second set of segments generated by grouping segments of the first set, based on pixel value and/or segment boundaries. The hierarchy can be generated top-down, where a first set is generated and then a second set is generated by dividing up segments of the first set, based on pixel value and/or segment boundaries. The hierarchy can be included in the compressed video data or omitted such that a decoder would have to independently generate it. The hierarchy can be two or more levels. The hierarchy can be used for editing, formatting and/or compressing frames, as well as associating metadata with elements of the frame and coding motion, residue or other kinetic information.

Segment-based encoding system using segment hierarchies

A decoder decodes compressed video data wherein nonkey frames are decoded with reference to other frames from the video data that are reference frames. The decoder generates at least a part of a segmentation of the reference frames for use in decoding nonkey frames. A nonkey frame is regenerated using kinetic information about the current frame and the reference frame segmentation. Kinetic information might include segment translation information. Where the segmentation used in encoding the compressed video data can vary among a plurality of segmentation schemes, the decoder determines which segmentation scheme is used from selection indications in the compressed video data or from previously decoded video data. The decoder might also use partial segmentation information, segmentation hints, partial segment canonical information and/or canonical hints in its segmentation process. The decoder might also process segment-related metadata extracted the compressed video data.

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Redwood Shores, CA, United States of America

Eniko Fodor