Subtle Medical, Inc.

Leland Stanford Junior University

General Electric Company

Ge Precision Healthcare LLC

Enhao Gong

John Mark Pauly

Greg Zaharchuk

Tao Zhang

Ben Andrew Duffy

Suchandrima Banerjee

Gajanana Keshava Datta

Gregory Zaharchuk

David Van Veen

Morteza Mardani Korani

Srivathsa Pasumarthi Venkata

Long Wang

Jonathan Tamir

Provided herein are methods for automated image quality control (QC). The method comprises: generating training data based at least in part on metadata obtained from a data augmentation process; training a model for a QC task based at least in part on the training data. The model is trained using a self-supervised learning algorithm.

Self-supervised learning for medical image quality control

A computer-implemented method is provided for improving live video quality. The method comprises: acquiring, using a medical imaging apparatus, a stream of consecutive image frames of a subject, and the stream of consecutive image frames are acquired with reduced amount of radiation dose; applying a deep learning network model to the stream of consecutive image frames to generate an image frame with improved quality; and displaying the image frame with improved quality in real-time on a display.

Systems and methods for real-time video enhancement

A computer-implemented method for transforming magnetic resonance (MR) imaging across multiple vendors is provided. The method comprises: obtaining a training dataset, wherein the training dataset comprises a paired dataset and an un-paired dataset, and wherein the training dataset comprises image data acquired using two or more MR imaging devices; training a deep network model using the training dataset; obtaining an input MR image; and transforming the input MR image to a target image style using the deep network model.

Systems and methods for magnetic resonance imaging standardization using deep learning

A computer-implemented method is provided for improving image quality with shortened acquisition time. The method comprises: determining an accelerated image acquisition parameter for imaging a subject using a medical imaging apparatus; acquiring, using the medical imaging apparatus, a medical image of the subject according to the accelerated image acquisition parameter; applying a deep network model to the medical image to generate a corresponding transformed medical image with improved quality; and combining the medical image and the corresponding transformed medial image using an adaptive mixing algorithm to generate output image.

Systems and methods for accurate and rapid positron emission tomography using deep learning

A method for diagnostic imaging with reduced contrast agent dose uses a deep learning network (DLN) [] that has been trained using zero-contrast [] and low-contrast [] images as input to the DLN and full-contrast images [] as reference ground truth images. Prior to training, the images are pre-processed [] to co-register and normalize them. The trained DLN [] is then used to predict a synthesized full-dose contrast agent image [] from acquired zero-dose and low-dose images.

Contrast dose reduction for medical imaging using deep learning

Methods and systems for synthesizing contrast images from a quantitative acquisition are disclosed. An exemplary method includes performing a quantification scan, using a trained deep neural network to synthesize a contrast image from the quantification scan, and outputting the contrast image synthesized by the trained deep neural network. In another exemplary method, an operator can identify a target contrast type for the synthesized contrast image. A trained discriminator and classifier module determines whether the synthesized contrast image is of realistic image quality and whether the synthesized contrast image matches the target contrast type.

System and method for synthesizing magnetic resonance images

A method of reducing radiation dose for radiology imaging modalities and nuclear medicine by using a convolutional network to generate a standard-dose nuclear medicine image from low-dose nuclear medicine image, where the network includes N convolution neural network (CNN) stages, where each stage includes M convolution layers having K×K kernels, where the network further includes an encoder-decoder structure having symmetry concatenate connections between corresponding stages, downsampling using pooling and upsampling using bilinear interpolation between the stages, where the network extracts multi-scale and high-level features from the low-dose image to simulate a high-dose image, and adding concatenate connections to the low-dose image to preserve local information and resolution of the high-dose image, the high-dose image includes a dose reduction factor (DRF) equal to 1 of a radio tracer in a patient, the low-dose PET image includes a DRF of at least 4 of the radio tracer in the patient.

Dose reduction for medical imaging using deep convolutional neural networks

A computer-implemented method is provided for improving live video quality. The method comprises: (a) acquiring, using a medical imaging apparatus, a stream of consecutive image frames of a subject; (b) feeding the stream of consecutive image frames to a first set of denoising components, wherein each of the first set of denoising components is configured to denoise an image frame from the stream of consecutive image frames in a spatial domain to output an intermediate image frame; (c) feeding a plurality of the intermediate image frames to a second denoising component, wherein the second denoising component is configured to (i) denoise the plurality of the intermediate image frames in a temporal domain and (ii) generate a weight map; and outputting a final image frame with improved quality in both temporal domain and spatial domain based at least in part on the weight map.

Systems and methods for real-time video denoising

A computer-implemented method is provided for improving image quality with shortened acquisition time. The method comprises: determining an accelerated image acquisition scheme for imaging a subject using a medical imaging apparatus; acquiring a medical image of the subject according to the accelerated image acquisition scheme using the medical imaging apparatus; applying a deep network model to the medical image to improve the quality of the medical image; and outputting an improved quality image of the subject, for analysis by a physician.

Systems and methods for improving magnetic resonance imaging using deep learning

Methods and systems are provided for improving model robustness and generalizability. The method may comprise: acquiring, using a medical imaging apparatus, a medical image of a subject; reformatting the medical image of the subject in multiple scanning orientations; applying a deep network model to the medical image to improve the quality of the medical image; and outputting an improved quality image of the subject for analysis by a physician.

Systems and methods for improving low dose volumetric contrast-enhanced MRI

A method of reducing radiation dose for radiology imaging modalities and nuclear medicine by using a convolutional network to generate a standard-dose nuclear medicine image from low-dose nuclear medicine image, where the network includes N convolution neural network (CNN) stages, where each stage includes M convolution layers having K&#xd7;K kernels, where the network further includes an encoder-decoder structure having symmetry concatenate connections between corresponding stages, downsampling using pooling and upsampling using bilinear interpolation between the stages, where the network extracts multi-scale and high-level features from the low-dose image to simulate a high-dose image, and adding concatenate connections to the low-dose image to preserve local information and resolution of the high-dose image, the high-dose image includes a dose reduction factor (DRF) equal to 1 of a radio tracer in a patient, the low-dose PET image includes a DRF of at least 4 of the radio tracer in the patient.

A method for diagnostic imaging with reduced contrast agent dose uses a deep learning network (DLN) [that has been trained using zero-contrast [and low-contrast [] images as input to the DLN and full-contrast images [as reference ground truth images. Prior to training, the images are pre-processed [to co-register and normalize them. The trained DLN [is then used to predict a synthesized full-dose contrast agent image [] from acquired zero-dose and low-dose images.

A method for diagnostic imaging includes measuring undersampled data y with a diagnostic imaging apparatus; linearly transforming the undersampled data y to obtain an initial image estimate {tilde over (x)}; applying the initial image estimate {tilde over (x)} as input to a generator network to obtain an aliasing artifact-reduced image x&#x306; as output of the generator network, where the aliasing artifact-reduced image x&#x306; is a projection onto a manifold of realistic images of the initial image estimate {tilde over (x)}; and performing an acquisition signal model projection of the aliasing artifact-reduced x&#x306; onto a space of consistent images to obtain a reconstructed image {circumflex over (x)} having suppressed image artifacts.

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Sunnyvale, CA, United States of America

Enhao Gong