National University of Singapore

Singapore Health Services Pte Ltd

60 Degrees Pharmaceuticals, LLC

Massachusetts Institute of Technology

Eng Eong Ooi

Satoru Watanabe

Subhash G Vasudevan

Geoffrey Stuart Dow

Jenny Low

Abhay Rathore

Glynn Morrish

Cynthia Sung

Mark Reid

Ram Sasisekharan

Kannan Tharakaraman

Kuan Rong Chan

Kitti Wing Ki Chan

Kenneth Goh

Choon Kit Tang

Swee Sen Kwek

The present invention relates to a method of generating a live attenuated vaccine. The present invention also relates to a live attenuated vaccine produced according to the method of the invention.

Rapid method of generating live attenuated vaccines

Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

Antibodies that bind zika virus envelope protein and uses thereof

Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered within onset of fever to 72 hours of fever onset due to dengue infection and then every 6 to 12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENV1-4 viral infections.

Dosing regimens of celgosivir for the treatment of dengue

Methods of preventing a disease resulting from a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I); a compound of Formula (I) can be first administered to an asymptomatic human subject followed by subsequent doses administered at least once daily. The methods of the invention can be used to prevent a disease resulting from primary and secondary DENV 1-4 viral infections. 

Dosing regimens of celgosivir for the prevention of dengue

Antibodies that bind Zika virus envelope protein and uses thereof

Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered within onset of fever to 72 hours of fever onset due to dengue infection and then every 6 to 12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENV 1-4 viral infections.

Dosing regiments of celgosivir for the treatment of dengue

Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I): A compound of Formula (I) can be administered within onset of fever to 72 hours of fever onset due to dengue infection and then every 6 to 12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENV1-4 viral infections. 

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Singapore, Singapore

Eng Eong Ooi