Nitrokemia Ipartelepek

Nehezvegyipari Kutato Intezet

Mta Mezogazdasagi Kutato Intezet

Endre Sumegi

Zoltan Kolonics

Jeno Pelyva

Miklos Kovacs

Elemer Tomordi

Miklos Nadasy

Laszlo Lendvai

Ervin Vertesi

Andras Vass

Balint Nagy

Kornelia Domjan Nee Pinter

Gyorgy Huszak

Bela Gyorfi

Laszlo J Szabo

Andras Haas

Taszlo Kulcsar

The invention relates to an improved method for the preparation of a 2',6'-dialkyl-N-alkoxymethyl-2-chloro-acetanilide compound of the general formula (I), ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are identical or different and stand for straight-chained or branched C.sub.1-4 alkyl groups. According to the invention a dialkyl aniline of the general formula (II), ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, is treated with aqueous formaldehyde solution in an apolar solvent at a temperature of 30.degree. to 80.degree. C., the solution of the resulting oxymethyl derivative formed with said apolar solvent is separated from the aqueous formaldehyde solution at an elevated temperature and then dehydrated, the resulting azomethine derivative is reacted with chloroacetyl chloride in the same apolar solvent medium, the resulting chloromethyl compound is reacted with an alcohol of the general formula (V),

Process for the preparation of

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Fuzfogyartelep, Hungary

Endre Sumegi