Aktiebolaget Hassle

E.i. Dupont De Nemours and Company

Enar I Carlsson

Gustav B Samuelsson

Bo T Lundgren

Kjell I Wetterlin

Nils H Persson

Arne E Brandstrom

Stig Ake Carlsson

Peder Bernhard Berntsson

Gert C Strandlund

Lars Ek

Sven E Sjostrand

Benny Roger Samuelsson

Hakan S Larsson

Bill B Gustafsson

Gunhild W Von Wittken Sundell

Bo T Lungren

Kenneth Lundstrom

Viola I Samuelsson-Junggren

Axel K Aberg

Bengt A Ablad

The present invention relates to new compounds of the formula I ##STR1## as well as their preparation, pharmaceutical preparations containing same, and method of treating acute myocardial infarction. The compounds which possess beta-adrenoceptor blocking activity are very shortacting and are preferably intended for treatment of acute myocardial infarction by administration by means of injection.

Substituted 3-phenoxy-1-alkoxycarbonylalkylamino-propanol-2-s having

A pharmaceutical preparation containing as active ingredient a compound of the formula ##STR1## or a therapeutically acceptable salt thereof in which formula R.sup.1 and R.sup.2 are the same or different and each selected from the group consisting of H, CF.sub.3, NO.sub.2, --COOCH.sub.3, --COOC.sub.2 H.sub.5, alkyl containing 1-7 carbon atoms, halogen, alkoxy, containing 1-5 carbon atoms, and alkanoyl containing 1-4 carbon atoms;

Pharmaceutical composition containing 2-(2-benzimidazolyl thiomethyl)

This invention relates to novel compounds of the general formula ##STR1## Representative compounds within the scope of the invention are ##STR2## The compounds are disclosed as being useful for treating symptoms and signs of cardiac failure by stimulating the .beta.-receptors of the heart. Methods of treatment using these compounds are discussed.

Heart active compounds and methods of use

Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and method for treating cardiovascular disorders by blocking the .beta.-receptors of the heart in combination with a peripheral vasodilating activity.

.beta.-Receptor blocking compounds and treatment of cardiovascular

Heart active compounds

An amine of the formula I set forth below ##STR1## and a method for the preparation thereof and treating cardiovascular diseases to exert its .alpha.-receptor blocking activity.

Amide substituted phenoxy propanol amines

Amines of the formula I ##STR1## method of preparing the same and pharmaceutical compositions and methods for treating cardiovascular disorders by blocking the .beta.-receptors of the heart in combination with a peripheral vasodilating activity.

Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation. Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

Phenoxy-hydroxypropylamines, their preparation, and method and

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Vastra Frolunda, Sweden

Enar I Carlsson