Micromass UK Limited

Waters Technologies Corporation

Emrys Jones

Steven Derek Pringle

Zoltan Takats

Keith George Richardson

Daniel Szalay

Lajos Godorhazy

Daniel Simon

Julia Balog

James Ian Langridge

Michael Raymond Morris

Tamas Karancsi

Frances Bolt

Stephen O'Brien

Anthony Hesse

Phillip Robert Bennett

David Alan MacIntyre

Pamela Pruski

Joseph D Michienzi

Wade P Leveille

Jeffrey Musacchio

Ian David Trivett

Richard Chapman

Alvin Chua

Tamás Karancsi

Gregory T Roman

Zoltán Takáts

Matt Henderson

Stephen Hattan

Mike Morris

Jeffery Mark Brown

Paul Robert Murray

Andrew Pawson

Arthur Blake

Mark William Towers

Matthew J Henderson

Dániel Szalay

Lajos Gödörházy

Júlia Balog

Gordon Kearney

Richard Schafer

Sara Stead

Dániel Simon

Zoltan Takáts

Phillip Bennett

Zoltán TAKÁTS

David Alan Macintyre

Philip Robert Bennett

A sprayer assembly for an ion source is disclosed. The sprayer includes a capillary having an outlet, a sheath for the capillary, and an elastic member. The sheath can move relative to the capillary between a first position in which the sheath covers the outlet of the capillary and a second position in which the outlet of the capillary is exposed. When the sheath moves from the first position to or towards the second position, the elastic member provides a restoring force that acts to restore the position of the sheath to or towards the first position.

Sprayer assembly for desi applications

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

Tissue analysis by mass spectrometry or ion mobility spectrometry

Sprayer assembly for DESI applications

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

Spectrometric analysis of microbes

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.

Cell population analysis

A method of producing ions from a sample is disclosed. The method comprises directing a spray of droplets onto a sample, and causing droplets comprising analyte from the sample to impact upon a surface so as to generate analyte ions.

Method of producing ions using spray droplets onto a sample

Scientific instrument

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target plant material; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said plant material.

Spectrometric analysis of plants

A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.

Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Rapid evaporative ionisation mass spectrometry ('REIMS') and desorption electrospray ionisation mass spectrometry ('DESI-MS') analysis of swabs and biopsy samples

An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.

Collision surface for improved ionisation

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

Ionisation of gaseous samples

Growing community of inventors

Manchester, United Kingdom

Emrys Jones