Eldex Laboratories, Inc.

Emmett L Durrum

Leonard L Manning

Stephen Amendola

Bruce W Erickson

A pump (20) has a housing (22) consisting of top (24), bottom (26), sides (28) and (30) and ends (32), (34), and (36) defining a plenum (38). An axially extending passage (40) is formed by the ends (32) and (34), through which flexible tubing (42) passes. The plenum (38) is connected to the passage (40). A pressure block (44) is slideably positioned in the plenum (38) for movement toward and away from the flexible tubing (42). The pressure block (44) has a rectangular opening (46), which receives a circular bearing (48) and a circular cam (50) which is eccentrically mounted on shaft (52). Conventional ball valves (54) and (56) are provided in the flexible tubing (42) above and below the pressure block (44). The lifetime of the tubing is substantially enhanced if the pressure block (24) depresses the tubing (42 ) no more than half of its inside diameter. When this limitation is followed, no creasing or similar localized severe distortion of the tubing (42) takes place. Rounded corners (58) and rounded surface (59) of the pressure block (24) extending a substantial length along the tubing (42) further help to avoid creasing or other severe distortion of the tubing (42).

Low fluid shear pump

A continuous flow peptide synthesizer (10) has reservoirs (12-42) for amino acid derivatives and reservoirs (154-156 and 161-167) for peptide synthesis reagents and solvents. A column (44) has column segments (224, 226, 228) forming stacked interconnected chambers for holding peptide synthesis polymeric resin supports (260). Each of the amino acid derivative reservoirs (12-42) and the reagent and solvent reservoirs (152-154 and 161-167) are connected through a separate controllable valve (46-76, 154-156 or 182-194) to the column (44). A pressurized source (106) of helium or other inert gas is provided for transferring the amino acid derivatives, reagents and solvents to the column (44). The column segments (224) are also used in a vessel (270) for confining the polymeric resin supports (260) in the vessel during cleavage of the peptides from the supports (260).

Continuous flow peptide synthesizer

A multichannel pump wherein the flow rate through each channel can be independently adjusted. In one embodiment there is a frame composed of upper and lower disc-shaped members which support a shaft in the center and a plurality of tube holders around the periphery. An eccentric cam is carried on the shaft and sequentially contacts resiliently deformable tubes in the respective tube holders. Each tube holder is independently adjustable toward and away from the path of travel of the cam and each can be removed for replacement or repair without affecting operation of the remainder of the apparatus. Also included are structures permitting the use of tubing having a low degree of elasticity, such as Teflon and the like. In another embodiment there is one or more cassette-like pumping units each of which contains two independently adjustable channels. The cassette-like units are so constructed that any reasonable number of the units can be combined to provide a multichannel pump having as many channels as needed.

Multichannel pump

High pressure pump

Data recording apparatus wherein the data is recorded on a sheet in a spatial arrangement or pattern corresponding to the spatial arrangement of a plurality of containers that constitute a part of a fraction collecting apparatus. The fraction collector operates by moving a nozzle carrying the discharge from a fractionating column along a path on which the containers are disposed. There is a data recording sheet and a pen supported for inscribing a graph on such sheet. The pen moves in unison with the nozzle and is displaced in a direction transverse to the path so that the spatial arrangement of the graph corresponds to the spatial arrangement of the containers.

Growing community of inventors

Menlo Park, CA, United States of America

Emmett L Durrum