Actelion Pharmaceuticals Ltd

Idorsia Pharmaceuticals Ltd

Olivier Houille

Emmanuel Meyer

Francis Hubler

Heinz Fretz

Eva Caroff

Kurt Hilpert

Sylvia Richard-Bildstein

Dorte Renneberg

Thierry Kimmerlin

David Lehmann

Marcel Keller

Rémy Castro

Loïc Jacob

Remy Castro

Alexia Chavanton-arpel

Oliver Allemann

Andrew Croxford

The invention relates to compounds of Formula (I) wherein X, Y, R, R, R, Rand Rare as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives

The invention relates to compounds of Formula (I) wherein n, X, Rand Rare as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

Hydroxyalkyl-piperazine derivatives as CXCR3 receptor modulators

The invention relates to compounds of Formula (I) wherein Rand Rare as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

(R)-2-methyl-piperazine derivatives as CXCR3 receptor modulators

The invention relates to compounds of Formula (I) wherein R, R, R, Rand Rare as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor. 

8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives

The invention relates to compounds of Formula (I), wherein ring A, X, (R), R, R, R, R, R, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives

The present invention relates to thiazole derivatives of formula I and their use as P2Yreceptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. 

Thiazole derivatives and their use as P2Y12 receptor antagonists

The invention relates to 2-phenyl-pyrimidine derivatives containing a phosphonic acid motif and their use as P2Yreceptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. (I). 

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The present invention relates to 2-phenyl-4-cyclopropyl-pyrimidine derivatives and their use as P2Yreceptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

2-phenyl-4-cyclopropyl-pyrimidine derivatives

The present invention relates to 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidine derivatives and their use as P2Yreceptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines

The present invention relates to compounds of formula I wherein R, R, R, R, R, R, n, W and Z are as defined in the application, their preparation and their use as P2Yreceptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

Substituted 2-phenyl-pyridine derivatives

The invention relates to 4-aminocarbonyl-pyrimidine derivatives and their use as P2Yreceptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals.

Pyrimidine derivatives and their use as P2Y12 receptor antagonists

The invention relates to 2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as P2Yreceptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. Formula (I). 

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Allschwil, Switzerland

Emmanuel Meyer