Schering Corporation

Merck Sharp + Dohme Corp.

Emma M Lees

M Arshad Siddiqui

Gerald Wayne Shipps, Jr

Yongqi Deng

Lianyun Zhao

Rumin Zhang

William T Windsor

Wolfgang Seghezzi

Patrick J Curran

David Parry

Charles W McNemar

Todd W Mayhood

Ronald J Doll

Vincent Stewart Madison

Janeta Popovici-Muller

Kurt C Gish

Alan W Hruza

Terrill K McClanahan

Thierry Olivier Fischmann

Jose S Duca

Ronald Herbst

William F Estacio

Frances Shanahan

David A Parry

Charles Wayne Mcnemar

The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

Compounds for inhibiting KSP kinesin activity

Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

High affinity quinoline-based kinase ligands

Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.

High affinity thiophene-based and furan-based kinase ligands

Purified genes encoding intracellular regulatory molecules from a human, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.

Intracellular regulatory molecules; related reagents

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Oakland, CA, United States of America

Emma M Lees