Agriculture Victoria Services Pty Limited

Emma Jane Isobel Ludlow

German Carlos Spangenberg

Timothy Ivor Sawbridge

Kathryn Michaela Guthridge

Simone Jane Rochfort

John White Forster

Ross Mann

Natasha Denise Brohier

Piyumi Niroshini Ekanayake

Inoka Kumari Hettiarachchige

Jatinder Kaur

Sophie Elizabeth Davidson

Simone Vassiliadis

Maia Andrea Rabinovich

Piyumi Ekanayake

The present invention relates to nucleic acids encoding amino acid sequences for the biosynthesis of janthitrem in janthitrem producing endophytes. The present invention also relates to constructs and vectors including such nucleic acids, and related polypeptides, regulatory elements and methods.

Metabolite production in endophytes

The present invention relates to a method for identifying and/or characterising an endophyte strain, said method including providing a plurality of samples of endophytes, subjecting said endophytes to genetic analysis; subjecting said endophytes to metabolic analysis and selecting endophytes having a desired genetic and metabolic profile. The present invention also relates to novel endophytes having a desired toxin profile wherein the endophyte produces significantly less toxic alkaloids compared with a control endophyte such as standard toxic (ST) endophyte; and/or significantly more alkaloids conferring beneficial properties compared with a control endophyte such as ST endophyte. The present invention also relates to endophyte variants having a desired genetic and metabolic profile, wherein said endophyte variants possess genetic and/or metabolic characteristics that result in a beneficial phenotype in a plant harbouring or otherwise associated with the endophyte variant. Preferably said endophyte variants are generated by polyploidisation or induced chromosome doubling.

Endophytes and related methods

Growing community of inventors

Viewbank, Australia

Emma Jane Isobel Ludlow