Astrazeneca Ab

Novexel Sa

Emilie Renaud

Camille Pierres

Benoit Ledoussal

Adel Kebsi

Marie-Edith Gourdel

Maxime Lampilas

David Alan Rowlands

The invention relates to nitrogenous heterocyclic compounds of formula (I): in which:

Substituted pyrazolo[3,4-E][diazepin-6-5(H)ones and analogues thereof, their preparation and their use as antibacterial medicaments

The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein:Rrepresents a (CH)&#x2014;NHradical, n being equal to 1 or 2;Rrepresents a hydrogen atom;Rand Rform together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH)&#x2014;(C(O))&#x2014;Rgroup, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and Rrepresenting a hydroxy group, in which case p is equal to 1, or an amino, (C-C)alkyl or di-(C-C)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom;

Nitrogen-containing heterocyclic compounds, their preparation and their use as antibacterial drugs

Growing community of inventors

Romainville, France

Emilie Renaud