Wisconsin Alumni Research Foundation

Emilie Porter

Samuel Helmer Gellman

Xifang Wang

Bernard Weisblum

Daniel H Appella

Matthew Woll

Paul LePlae

Hee-Seung Lee

Disclosed are &#x3b2;-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the &#x3b1; and &#x3b2; carbons of the peptide backbone and &#x3b2;-polypeptides made from such monomers. Method of generating combinatorial libraries of polypeptides containing the &#x3b2;-peptide residues and libraries formed thereby are disclosed.

Beta-amino acids

Disclosed are antimicrobial compositions containing &bgr;-peptides and methods of inhibiting microbial growth in mammals using the compositions. The &bgr;-peptides present in the compositions contain ring structures in the peptide backbone which limit the conformational flexibility of the peptide backbone.

Antimicrobial compositions containing &bgr;-amino acid oligomers

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Madison, WI, United States of America

Emilie Porter