Centre National De La Recherche Scientifique

Macopharma, S.a.s.

Maco Pharma Societe Anonyme

Macopharma

Emilie Bessy

Gregory Henard

Christophe Hupin

Sonia Dakhli

Laurent Ducoroy

Laurent Fouchet

Pascal Marmey

Pierre Lutz

Grégory Henard

A filtration unit to selectively remove leukocytes from fluids containing platelets and systems including a filtration unit are provided. In one embodiment, a filtration unit is provided including an outer casing enclosing a porous element which includes a leukocyte-removal medium with a coating. The coating includes a polymer containing a main hydrophobic chain and a hydrophilic poly(ethylene oxide) side chain and having a mass average molar mass in the range of from about 1,000 g/mol to about 20,000 g/mol. The hydrophilic poly(ethylene oxide) side chain includes from 9 to 50 ethylene oxide units, and the mass percentage of the poly(ethylene oxide) side chain is less than about 50% of the mass average molar mass of the polymer.

Leukocyte filtration unit with reduced platelet adhesion

A method for grafting a porous element for leucodepletion by adsorption and/or filtration of a biological fluid, such as blood or a blood component, which method comprises the steps of impregnating the porous element with a solution containing a poly(ethylene oxide) having identical or different functional end groups; and applying an ionizing treatment to the impregnated porous element so as to ensure covalent cross-linking between the poly(ethylene oxide) and the porous element.

Method for grafting a porous element for leucodepletion

Growing community of inventors

Sainte Maxime, France

Emilie Bessy