University of Pennsylvania

American Heart Association, Inc.

Emile R Mohler, Iii

Arjun Gaurang Yodh

Jonni Moore

Stephen M Hahn

Harry Quon

Joel H Greenberg

Mark G Burnett

Wade T Rogers

Guoqiang Yu

Jana M Schmierer

John A Detre

Turgut Durduran

This disclosure provides for compositions and methods that can be used to predict an individual's risk for experiencing a cardiovascular event following a surgical procedure (e.g., a non-cardiac surgical procedure).

Compositions and methods for predicting post-surgical cardiovascular events

An embodiment of the invention includes a device, system and method for determining the characteristics of deep tissue. The novel method includes measuring blood flow rate and oxygenation characteristics of the tissue, and determining oxygen metabolism of the tissue as a function of the measure blood flow rate and measure oxygenation. The blood flow rate characteristics are measured as a function of light fluctuations caused by the tissue, while the oxygenation characteristics are measured as a function of transmission of light through the tissue with respect to the wavelength of light. The tissue may be layered tissue, for example, a portion of a brain. The tissue characteristics may be measured during times of varying levels of exercise intensity.

Optical measurement of tissue blood flow, hemodynamics and oxygenation

Growing community of inventors

Philadelphia, PA, United States of America

Emile R Mohler, Iii