Centre National De La Recherche Scientifique

Other

Agence Nationale De Valorisation De La Recherche (anvar)

Institut National De La Sante Et De La Recherche Medicale

Adir Et Compagnie

Sanofi

Universitè De Montpellier

Rhone-poulenc Sante

Institut Curie

Agence Nationale De Valorisation De La Recherche

Institute Curie

Institute of Experimental Botany, Academy of Science of the Czech Republic

Sanofi and Centre National De La Recherche Scientifique

Université Montpellier 2 Sciences Et Techniques

Institut Botanique Expérimentale

Emile R Bisagni

David Grierson

Christian Rivalle

Chi Hung Nguyen

Luc Montagnier

Jean-Claude Chermann

Claude Monneret

Francoise Wendling

Pierre Tambourin

Anne-Marie Aubertin

Claire Ducrocq

Michel Legraverend

Alain Pierre

Ghanem Atassi

Laurent Meijer

Claude Guillonneau

Yves Charton

Dietrich Averbeck

Valerie Dolle

Jamal Tazi

Miroslav Strnad

Jacqueline Gruest

Abdellah Benjahad

Nicolas Guilbaud

Stephane Leonce

Dominique Mabire

Louis Dubertret

Marilys Greletepouse Rautureau

Chi-Hung Nguyen

Ethel Moustacchi

Jérôme Guillemont

Francois Zajdela

Jacqueline Morin

Gérard Sanz

Paul Vigny

Chi Hung N'Guyen

Dubertret Louis

Johann Soret

Jocelyne Blais

Laurence Decrane

Dora Papadopoulo

Philippe Jeanteur

Jacqueline Moron

Silvano Nocentini

Maria N Schwencke

Alain Civier

Rosette Lidereau

Hung C Nguyen

Val&eacute;rie Dolle

Paul M De Cointet

Nguyen Chi Hung

Michel Ventura

Odile Pepin

Marie-Line Andreola

Andre Kirn

Laura Tarrago-Litvak

This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.

Purine derivatives having, in particular, anti-proliferative properties, and their biological uses

The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromosome 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (Survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.

Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process

The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, Calkyl or Calkenyl; X is (a-2) with q and r being O and Z being O, S or SO; Ris aryl; Ris selected from formyl; Calkyloxycarbonylalkyl; Het; HetCalkyl, Calkylthio; Calkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; Ris selected from formyl; Calkyl optionally substituted with one or two Calkyloxy; Ris hydrogen, with HTV inhibiting properties 

Pyridinone and pyridinethione derivatives having HIV inhibiting properties

3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of HIV related diseases

The present invention is concerned with 3-(amino- or aminoalkyl)pyridinone derivatives which inhibit the reverse transcriptase of the Human Immunodeficiency Virus (HIV). It relates moreover to the use of such compounds for treating HIV-related diseases. Furthermore it relates to a process for the preparation of these compounds.

3-(Amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of HIV related diseases

This invention provides 2-, 6, and 9-substituted purine derivatives having, in particular, antiproliferative properties, and suitable for use as pharmaceutical compositions and herbicidal compositions. Also provided are pharmaceutical compositions and herbicidal compositions comprising the 2-, 6, and 9-substituted purine derivatives, and methods of treatment using the 2-, 6, and 9-substituted purine derivatives.

Purine derivatives having, in particular, antiproliferative properties, and their biological uses

The compounds of formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and A are as defined in the description, their optical isomers and N-oxides, and pharmaceutically acceptable addition salts thereof with an acid or base, and the use thereof as anti-tumor agents.

Ellipticine compounds

4-Aryl-thio-pyridin-2(1H)-ones, medicines containing them and their uses

The compounds of formula: ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and A are as defined in the description, their optical isomers and N-oxides and addition salts thereof with a pharmaceutically acceptable acid or base, and their use as anti-tumour agents.

New pyridobenzoindole derivatives of general formula (I), in which R is H or alkyl (1 or 2 C), alk is straight or branched alkylene (2 to 4 C), R.sub.1 denotes a hydrogen atom or an alkyl radical (1 or 2 C), R.sub.2 denotes a hydroxy or methoxy radical, and R.sub.3 is methyl or ethyl and their addition salts with acids, useful as antitumor agents. ##STR1##

Pyridobenzoindole derivatives, their preparation and compositions which

To prepare the compound (I), a lithiation of the compound (II) is performed, an aldehyde (IV) is reacted with the compound (III) formed, leading to the secondary alcohol (V) which is subjected to a reduction leading to the compound (VI), which is then subjected to a hydrolysis (of the dioxolane group)/cyclization/dehydration reaction. The procedure may be followed by a nucleophilic substitution reaction of the chlorine. The compounds (a) below exhibit antitumor activity. ##STR1## R=C.sub.1 -C.sub.3 alkyl; Ar=aromatic or polycyclic aromatic group; R.sub.1 and r.sub.2 =H or C.sub.1 -C.sub.3 alkyl; and n=2 to 4. No drawing.

Method for preparing 1-chloro-5-alkylisoquinolines condensed with

The present invention relates to new compounds which are the 1,2-dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b)indoles with the formula (I): ##STR1## in which R represents hydrogen or an alkoxy or aryl carbonyloxy group. These compounds are intermediates of synthesis in the preparation of compounds which can be used in the pharamaceutical industry. The invention is also concerned with their synthesis.

1,2-dihydro-4-methyl-1-oxo-5H-pyrido(4,3-b)indoles and the process for

The present invention concerns derivatives of 5H-pyrido[4,3-b]-indole with the following general formula: ##STR1## in which n represents a whole number from 2 to 4, R.sub.1 represents hydrogen or a lower alkyl group; R.sub.2 represents hydrogen, a hydroxy group or a lower alkyloxy group; R.sub.3 and R.sub.4 represents hydrogen, a lower alkyl group or hydroxyalkyl group, R.sub.5 can be identical or different and represents hydrogen, a hydroxy group or a lower alkyl group, as well as the tautomeric forms and the addition salts with pharmaceutically acceptable mineral or organic acids. The invention also concerns their preparation process, and their use as medicaments.

Derivatives of pyridoindole, having anti-tumor properties

Pyrido (3,4', 4,5) furo (3,2-g) coumarins or pyrido (3,4-h) psoralens having formula I ##STR1## wherein R is a hydrogen radical or a lower alkyl group having from 1 to 4 carbon atoms and R' is a methyl group or a methoxy group. These compounds are photobiologically active and are useful or medicinals and pharmaceutical compositions in association with ultraviolet radiation for treating skin diseases and as cosmetic compositions for skin pigmentation.

(3,4';4,5)-Pyrido (3,2-g)-furo coumarins or (3,4-h) pyrido psoralens

Monofunctional psoralen derivatives having the general formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group having from 1 to 4 atoms, preferably a methyl radical, or a lower alkoxy radical having from 1 to 4 carbon atoms, preferably a methoxy radical are described. The derivatives are photobiologically active and are useful in photochemical therapy and in cosmetics.

(3,4-c)-Pyrido psoralens, process of preparation, application in

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Orsay, France

Emile R Bisagni