Parcor

Sanofi

Emile H Braye

Joel Radisson

Andre Bousquet

Jean-Marie Ollivier

The invention has as its subject a process for the preparation of thienylethylamines of the formula

Process for the preparation of thienylethylamines

The present invention relates to a process for the preparation of thieno[3,2-c]pyridine, wherein 4,5,6,7-tetrahydrothieno[3,2-c]pyridine is catalytically dehydrogenated in the gaseous phase at a temperature of from about 350.degree. to about 600.degree. C. using a catalyst comprising at least one metal or metal oxide of which the metal component is selected from chromium, nickel, molybdenum, cobalt and tungsten, optionally in association with magnesium, sodium or iron or the oxides thereof, the catalyst being deposited on an inert carrier.

Process for the preparation of thieno[3,2-c]pyridine

This invention relates to a process for the preparation of compounds having the general formula: ##STR1## in which: R.sub.1 represents a hydrogen atom, an optionaly substituted alkyl, aryl or aralkyl radical; R.sub.2 and R.sub.3 are the same or different and represent independently a hydrogen atom, a lower alkyl, aryl or heterocyclic radical; and R.sub.4 represents a hydrogen atom or an alkyl, cycloalkyl, alkoxy carbonyl, carboxy, aryl or heterocyclic radical, comprising reacting a compound having the formula: ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are as defined above, with a compound having the formula: ##STR3## in which R.sub.4 is as defined above; X is a halogen atom, or an optionally substituted alkoxy, thioalkyl or amino group; and Y represents an optionally substituted alkoxy, thioalkyl or amino group, or a group of the formula: ##STR4## in which R is a lower alkyl or aryl radical; or both the groups X and Y, together with the carbon atom to which they are attached, form a 6-membered hexahydro-S-triazinic, trioxannic or trithianic heterocyclic nucleus, in an inert solvent, at a temperature between 0.degree. and 150.degree. C. and in an anhydrous medium, and, if desired, liberating the free base.

Process for the preparation of thienopyridine derivatives

This invention relates to a process for the preparation of compounds of the formula: ##STR1## in which R.sub.1 and R.sub.2 may represent hydrogen or a lower alkyl or optionally substituted phenyl radical, comprising aminating a derivative of the formula: ##STR2## in which R.sub.3 is an optionnally substituted alkyl, aryl or aralkyl group, and R.sub.1 and R.sub.2 are as defined for formula (I).

Process for the preparation of 2-(2-thienyl)-ethylamine and derivatives

This invention relates to a process for the preparation of thieno-pyridine derivatives having the structural formula: ##STR1## in which R.sub.1 represents an optionally substituted alkyl, aryl or aralkyl radical, and R.sub.2 and R.sub.3 represnt each hydrogen or a lower alkyl, aryl or heterocyclic radical, comprising:

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Auterive, France

Emile H Braye