Ucb S.a.

Daicel Chemical Industries, Ltd.

Ucb Pharma, S.a.

Novasep

Novasep Process

Emile Cavoy

Michel Hamende

Vincent Zimmermann

Michel Deleers

Celal Ates

John Surtees

Anne-Catherine Burteau

Violeta Marmon

Jean-Pierre Canvat

Olivier Ludemann-Hombourger

Roger-Marc Nicoud

Didier Bouvy

Célal Ates

Vincent Zimmerman

Sylvie Lehoucq

Tooru Futagawa

The present invention relates to an improved process for the preparation of (S)-(&#x2212;)-&#x3b1;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein Ris methyl or ethyl; and Ris C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes. 

Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues

The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds 

Piperazine derivatives and their use as synthesis intermediates

The present invention relates to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide by separation of a racemic mixture using multiple column chromatography.

Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide

The present invention relates to an improved process for the preparation of (S)-(&#x2212;)-&#x3b1;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein Ris methyl or ethyl; and Ris C?2#191&#x2013;C?4#191 alkyl, C?2#191&#x2013;C?4#191 alkenyl or C?2#191&#x2013;C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes 

Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues

Process for preparing (S) and (R)&#x2014;2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide

The invention relates to a process for separating at least one component of a mixture in a simulated moving bed, in which each of the chromatographic columns that contains an adsorbent has a ratio of L (length) to D (diameter) of between 0.01 and 0.34, and the ratio of L (length in n columns) to D (diameter) is between 0.06 and 2.3. It is possible to apply an axial dynamic pressure on each of the upper columns that exceeds the pressure drop of all of the columns.

Process for separation in a simulated moving bed of at least one component in columns that have a suitable length to diameter ratio

The present invention relates to a process for preparing (S)- and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide and (R)-.alpha.-ethyl-2-oxo-1-pyrrolidineacetamide. According to this process, the enantiomeric resolution of the racemic mixture of .alpha.-ethyl-2-oxo-1-pyrrolidineacetamide is carried out by simulated mobile bed chromatography, using at least three columns filled with chiral stationary phase. This process makes it possible to achieve good production efficiency on the industrial scale.

Process for preparing (s)- and

Levetiracetam is prepared by optical resolution of etiracetam by means of preparative high performance liquid chromatography or continuous simulated moving bed chromatographic system using silica gel supporting amylose tris(3,5-dimethylphenylcarbamate) as a packing material.

Process for the preparation of levetiracetam

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Ham-sur-Heure, Belgium

Emile Cavoy