Pharm-eco Laboratories, Inc.

Interneuron Pharmaceuticals, Inc.

Emile Al-Farhan

Yesh P Sachdeva

Richard L Gabriel

Salah A Zahr

Siya Ram

Biman Pal

Jaechul Shim

Bing Cai

Emile M Bellott

Kenneth W Locke

Kay Jorgenson D'Orlando

Subramaniam Krishnananthan

Michael D Nohrden

Reem M Haider

Robert Stevenson

Milind P Sant

Ahmed Hilmy

Disclosed is a method of preparing a compound represented by the following structural formula: ##STR1## and physiological salts thereof. R.sup.1 is --H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R.sup.2 is a substituted or unsubstituted 2-hydroxy-1-ethyl group. Ring A is a substituted or unsubstituted aryl group. Ring B is substituted or unsubstituted at position two. The method comprises reacting a substituted or unsubstituted aryl hydrazine or salt derived from a substituted or unsubstituted aryl hydrazine with a compound represented by the following structural formula: ##STR2##

Method for making substituted indoles

Amino acid-derived diaminopropanols

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

Method of forming amino acid-derived diaminopropanols useful as chemical

Method forming protease inhibitor synthetic intermediates

The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.

This invention relates to novel substituted tryptamine and phenalkylamine and related compounds, pharmaceutical compositions thereof and methods of using said compounds.

Substituted tryptamines phenalkylamines and related compounds

Method preparing amino acid-derived diaminopropanols

This invention relates to novel substituted tryptamine and phenalkylamine and related compounds, pharmaceutical compositions thereof and methods of using said compounds and compositions for a number of pharmaceutical indications including (but not limited to): 1. central nervous system and psychiatric disorders (e.g., sleep disorders, epilepsy and other convulsive disorders, anxiety, psychiatric diseases, neurodegenerative diseases, fever); 2. chronobiological-based disorders (e.g., jet lag, delayed sleep syndrome, shift-work, seasonal affective disorder); 3. endocrine indications (e.g., contraception and infertility, precocious puberty, premenstrual syndrome, hyperprolactinemia, growth hormone deficiency); 4. cancer and other proliferative diseases; 5. immune system disorders and conditions associated with senescence; 6. ophthalmological diseases; 7. animal breeding (e.g., regulation of fertility, puberty, pelage color).

Substituted tryptamines, phenalkylamines and related compounds

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Dedham, MA, United States of America

Emile Al-Farhan