Neuronexus Technologies, Inc.

Medtronic Bakken Research Center B.v.

Sapiens Steering Brain Stimulation B.v.

Emil Toader

Pieter Gerrit Blanken

Hubert Cécile François Martens

Franciscus Paulus Maria Budzelaar

David J Anderson

Michel Marcel Jose Decré

Michel Marcel Jose Decre

A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes. The method comprises sequentially applying a test current to n stimulation electrodes, n being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, for each test current at one of the n stimulation electrodes, measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, from the stimulation settings and the measured excitation voltages, deriving a coupling matrix, an element in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes, and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.

Method and system for determining settings for deep brain stimulation

A method and a control system () are provided for determining a relation between stimulation settings for a brain stimulation probe () and a corresponding V-field. The brain stimulation probe () comprises multiple stimulation electrodes (). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (). The method comprises sequentially applying a test current to n stimulation electrodes (), n being a number between 2 and the number of stimulation electrodes () of the brain stimulation probe (), for each test current at one of the n stimulation electrodes (), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes () of the brain stimulation probe (), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (&#x3b7;)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.

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Eindhoven, Netherlands

Emil Toader