Toray Industries, Inc.

Emiko Sano

Jun Utsumi

Masanobu Naruto

Tetsuo Sudo

Kazuo Hosoi

Katsuaki Kojima

Makoto Kihara

Masahiko Iizuka

Tatsutoshi Nakahata

Genji Kawano

Ryuhei Tanaka

Hidenobu Kubota

Tetsuo Kubo

Keizo Hanada

Shingou Sakurai

Shigeru Ichikura

Atsushi Komiyama

A hemopoietic stem cell augmenting agent in which at least one type of hepatocyte growth factor is contained as an active component is provided. The hepatocyte growth factor has an augmenting activity on undifferentiated pluripotent hemopoietic stem cells and is useful as a hemopoietic stem cell augmenting agent for treatment of bone marrow suppression and for treatment of bone marrow malfunctions and furthermore is useful for in vitro growth of peripheral blood stem cells and bone marrow stem cells. Furthermore, a hepatocyte growth factor derived from human normal fibroblasts which is considered to be a type of hepatocyte growth factor can be obtained by genetic recombination techniques, and said factor is also useful as a hemopoietic stem cells augmenting agent.

Hemopoietic stem cell multiplier

The present invention relates to compositions containing human interleukin-6 with sugar chains, a process for preparing human interleukin-6 by culturing cells in a medium containing ascorbic acid or any of its derivatives, and a process for purifying a crude raw human interleukin-6 solution by chromatography using a carrier with heparin bound. The present invention has allowed the production of high quality human interleukin-6 compositions with sugar chains, and their application to medicines. Furthermore, it has established a process for massproducing human interleukin-6.

Interlekin-6 compositions, and a production process thereof

In producing interferon by treating animal cells proliferated on a microcarrier with an interferon inducer, the cells on the microcarrier are treated with a negatively charged water-soluble macromolecular material.

Process for producing interferon

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Yokohama, Japan

Emiko Sano