Toa Eiyo Ltd.

Emiko Iimori

Kazuhiro Uemoto

Masayuki Kageyama

Yoshimichi Sato

Naoki Okada

A compound represented by general formula (1) a pharmaceutically acceptable salt thereof or a solvate thereof; wherein Ar represents an aryl group, or a 5- or 6-membered heteroaryl group containing a nitrogen atom, an oxygen atom or a sulfur atom; Y represents, for example, a hydrogen atom or a C-Calkyl group; A represents a C-Calkylene chain which may be substituted with two C-Calkyl groups; X represents a hydrogen atom or a halogen atom; V represents an oxygen atom or a methylene chain; and R represents a group selected from the formulae below: 

4-aminomethylbenzoic acid derivative

Provided is a pharmaceutical agent containing a compound represented by General Formula (1), a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein A represents a C-Clinear alkylene group, in which one methylene group is optionally substituted with O or S;n represents an integer of from 3 to 5;Xand Xeach independently represent CH or N;Wand Weach independently represent a carboxyl group or a tetrazolyl group;V represents a C-Clinear or branched alkylene group, in which one methylene group is optionally substituted with O or S; andR represents a substituted phenyl group, for example.

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Ota-ku, Japan

Emiko Iimori