Teijin Pharma Limited

Emi Yokoyama

Jun Shibata

Hidekazu Watanabe

Gen Unoki

Kosuke Sasaki

Kenichiro Takagi

Kyohei Horie

Shinnosuke Hosoda

A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (R)-A-(CRR)&#x2014;(CRR); A represents aryl, heteroaryl; Rrepresents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; Rrepresents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, RRNCO&#x2014;; Rand Rrepresent hydrogen, halogen, alkyl, phenyl, and cycloalkyl. 

Aminoazole derivative

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Tokyo, Japan

Emi Yokoyama