Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Emi Shoji

Kenji Shibata

Nobuo Hanai

Motoo Yamasaki

Kazuyasu Nakamura

Yutaka Kanda

Kenya Shitara

Akiko Furuya

Kazuhisa Uchida

Toyohide Shinkawa

Hideharu Anazawa

Naoko Yamane

Rinpei Niwa

Susumu Imabeppu

Mikiko Sakurada

A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer.

Method for producing recombinant antibody and antibody fragment thereof

Method for treating the Th2-mediated disease

Method for treating Th2-mediated disease

Recombinant antibody and antibody fragment

Growing community of inventors

Machida, Japan

Emi Shoji