Kabushiki Kaisha Toshiba

Toshiba Medical Systems Corporation

Emi Nozaki

Eiichi Akahoshi

Mitsuko Ishihara

Katsuyuki Naito

Saeko Saruwatari

The present embodiment provides a compound represented by the formula (1):Q-CHR  (1)(Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.

Lipid particle, composition comprising lipid particle, and method for delivering activators to cell

The present embodiment provides a compound represented by the formula (1):Q-CHR&#x2003;&#x2003;(1)(Q is a nitrogen-containing aliphatic group containing two or more tertiary nitrogens but no oxygen, and R is an aliphatic group containing a biodegradable group). From the compound in combination with other lipids such as a lipid capable of reducing aggregation, lipid particles can be formed. Further, the compound can be used for a pharmaceutical composition to deliver an activator into cells.

Biodegradable compound, lipid particle, composition comprising lipid particle, and kit

According to one embodiment, a nucleic acid condensing peptide includes one terminal having a first sequence RRRRRR and another terminal having a second sequence RQRQR. Between the first sequence and the second sequence, none or one or more intermediate sequences each consisting of RRRRRR or RQRQR are included. Further, of the first sequence, the second sequence and the intermediate sequences, two or more neutral amino acids are included between any two sequences adjacent to each other.

Nucleic acid condensing peptide, nucleic acid condensing peptide set, nucleic acid delivery carrier, nucleic acid delivery method, cell production method, cell detection method and kit

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Yokohama, Japan

Emi Nozaki