Nihon Medi-physics Company, Limited

Bio Med Core Incorporation

Emi Kaneko

Akio Hayashi

Masahito Toyama

Toshiyuki Shinmura

Masahiro Murakami

Daisaku Nakamura

Yasushi Arano

Fumie Kurosaki

Soichi Nakamura

Shinji Tokunaga

Soichi Takasaki

A composition including a radioactive fluorine-labeled amino acid compound is provided, which can be prevented from radiolysis. Disclosed is a composition which includes a solution containing a radioactive fluorine-labeled amino acid compound as an effective ingredient, in which the pH value of the solution is kept at 2.0-5.9, more preferably 2.0-4.9 in order to inhibit radiolysis. Also, it is possible to further inhibit radiolysis by adding thereto a pharmaceutical additive capable of inhibiting radiolysis, such as a sugar, a sugar alcohol and a sugar lactone, while the pH is kept at 2.0-5.9.

Radioactive diagnostic imaging agent

A process is provided for producing [F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for producing a radioactive fluorine-labeled organic compound, including a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1): wherein Ris a linear or branched C-C-alkyl chain or an aromatic substituent, and Ris a protecting group; wherein X is sodium or potassium; and 

Process for production of radioactive fluorine-labeled organic compound

An object of the present invention is to provide a method of producing liposome wherein a complex of a short half-life metallic radioactive nuclide such asTc and CD is encapsulated, with radiochemical yield and purity enabling practical application. The present invention provides a method of producing a liposome wherein a complex of a short half-life metallic radioactive nuclide and ethylenedicysteine (CD) is encapsulated, which comprises mixing a complex of a short half-life metallic radioactive nuclide and N-[2-(1H-pyrrolylmethyl)]-N'-(4-penten-3-on-2)-ethane-1,2-diamine with an ethylenedicysteine (CD)-encapsulated liposome, and incubating the mixture.

Method of encapsulating metal complex within liposomes

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Chiba, Japan

Emi Kaneko