Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Japan as Represented by President of National Cancer Center

Kyowa Kirin Co., Ltd.

Emi Hosaka

Kazuyasu Nakamura

Nobuo Hanai

Motoo Yamasaki

Kazuhisa Uchida

Toyohide Shinkawa

Yutaka Kanda

Naoko Yamane

Mitsuo Satoh

Kazuya Yamano

Hideharu Anazawa

Susumu Imabeppu

Kenya Shitara

Masamichi Koike

Akiko Shimizu

Akiko Furuya

Atsushi Ochiai

Yuji Ohki

Toshio Ota

So Ohta

Yuka Sasaki

Norihiko Shiraishi

Yoko Kato

Susume Sekine

Akiko Tanaka

A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.

Human CDR-grafted antibody and antibody fragment thereof

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Antibody composition-producing cell

The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.

Method of modulating the activity of functional immune molecules

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependant cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

The present invention relates to a cell and mammal in which GDP-mannose 4,6-dehydratase is knocked-out. The cell and mammal are useful for the production of an antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, such as an antibody useful for treating various diseases. The cell and mammal are also useful for the production of a fragment of the antibody, and a fusion protein having the Fc region of the antibody.

Cells with altered fucosylation and producing antibodies therefrom

Glycoengineered, recombinant antibody

The present invention relates to a cell for the production of an antibody molecule such as an antibody binding to ganglioside GM2, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Antibody composition exhibiting cellular cytotoxicity due to glycosylation and containing ganglioside GM2 binding antibody

The present invention relates to a cell for the production of an anti-IL-5 antibody molecule having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

Anti-il-5 antibody composition exhibiting cellular cytotoxicity due to glycosylation

Growing community of inventors

Machida, Japan

Emi Hosaka