The General Hospital Corporation

Massachusetts Institute of Technology

Washington University

Emery Neal Brown

Patrick L Purdon

Li-Huei Tsai

Chinnakkaruppan Adaikkan

Anthony James Martorell

Hannah Iaccarino

Demba Ba

Eran A Mukamel

Oluwaseun Johnson-Akeju

Laura D Lewis

Brandon M Westover

Ken Solt

ShiNung Ching

Emad N Eskandar

Joseph F Cotten

Pavitra Krishnaswamy

Michael J Prerau

Mriganka Sur

Sridevi V Sarma

Riccardo Barbieri

Steven J Skates

Kathleen J Koenigs

Sandya Subramanian

Ben Palanca

Michael Behr

Christian Guay

Wasim Q Malik

James Matthew Schummers

Rose T Faghih

Jacob A Donoghue

Seong-Eun Kim

Aaron K Styer

Jessica J Chemali

Frederick M Debros

Anne Caroline Smith

Aylin Cimenser

Oluwaseun Akeju

Methods and compositions, e.g., compositions for intravenous administration, comprising dextroamphetamine and/or lisdexamfetamine for use in reversal of dexmedetomidine sedation.

Dextroamphetamine and lisdexamfetamine to reverse dexmedetomidine sedation

Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject's brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.

Systems and methods to infer brain state during burst suppression

A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.

Methods and devices for providing a stimulus to a subject to induce gamma oscillations

Among the various aspects of the present disclosure is the provision of methods and systems for (i) modulating, enhancing, or maintaining slow waves using phase-locked neurostimulation; (ii) modulating, enhancing, or maintaining unconsciousness; or (iii) reducing the amount of anesthesia required in a subject. Briefly, therefore, the present disclosure is directed to applying neurostimulation to the brain of a subject to enhance anesthesia, thereby decreasing drug requirements of anesthesia.

Methods and systems for modulating unconsciousness or anesthesia in a subject

Systems and methods for tracking sympathetic-driven arousal state (SDAS) including nociception under anesthesia is described herein. The method includes obtaining heart rate variability and electrodermal activity of a subject. Point process models are generated for the heart rate variability and the electrodermal activity. A multimodal approach is implemented to determine a state space framework based on these point process models. SDAS can be estimated using the state space framework. In some implementations, an anesthesiologist can modify the dosage of drugs administered to the subject based on this estimation.

Tracking nociception under anesthesia using a multimodal metric

Systems and methods for monitoring a subject under, or suspected to be under, the influence of one or more drugs are provided. In one aspect, a method comprises controlling one or more sensors of a monitoring device to acquire physiological signals from a subject suspected to be under the influence of one or more drugs, and assembling a set of physiological data using the acquired physiological signals. The method also includes generating, using a processor of the monitoring device, physiological markers characteristic of the influence of the one or more drugs by analyzing the set of physiological data, and correlating the physiological markers with a drug profile characterizing the one or more drugs affecting the subject. The method further includes proving to a user a report indicating the drug profile characterizing the one or more drugs affecting the subject.

Systems and methods for monitoring a subject under the influence of drugs

A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.

Systems and methods for predicting arousal to consciousness during general anesthesia and sedation

A method and system for determining the state of a patients brain under anesthesia. The present invention recognizes that anesthesia compounds induce different signatures in physiological characteristics of the patient under anesthesia and aids interpretation of physiological characteristics and signatures therein based on a selected anesthesia compound. The present invention aids the monitoring and/or interpreting of the physiological characteristics to a state of the patient's brain.

System and method for tracking brain states during administration of anesthesia

The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general anesthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.

Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine

Methods and products for automated real-time ovarian follicular detection, monitoring and analysis are provided. The devices and methods allow for remote or local analysis, while minimizing or eliminating the need for technician review of the output images. The methods are useful in human and non-human subjects including companion animals and other animals such as endangered species.

System and method for automated ovarian follicular monitoring

The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.

The present disclosure features systems and methods for analyzing student learning and calibrating the difficulty of questions on a test or examination. In one embodiment, a method for analyzing the learning of a student includes administering, by an assessment agent, a task to a student, the task comprising a question having an associated difficulty. The assessment agent receives a response to the question from the student and evaluates the response to generate an observable, the observable comprising information related to the response. A posterior determination of the student's ability is then calculated by incorporating the observable into an ability model associated with the student, and the posterior determination of ability may be compared with the difficulty of the question, a skill acquisition probability, or other measure. The student's response, or a plurality of responses from students within a cohort, may be used to determine the difficulty of each question.

System and method for real-time analysis and guidance of learning

Systems and methods for analyzing electrophysiological signals acquired from a subject are provided. In some aspects, a method includes receiving electrophysiological signals acquired from a subject using one or more sensors, and assembling a set of time-series data using the acquired electrophysiological signals. The method also includes analyzing the set of time-series data using a state-space multi-taper framework to generate spectral information describing the electrophysiological signals, and determining a brain state of the subject using the spectral information. The method further includes generating a report indicative of the determined brain state.

Systems and methods for analyzing electrophysiological data from patients undergoing medical treatments

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Brookline, MA, United States of America

Emery Neal Brown