Psychogenics Inc.

Carnegie Mellon University

American Biogenetic Sciences, Inc.

Sunovion Pharmaceuticals Inc.

Pgi Drug Discovery LLC

Totalekidz LLC

Daniela Brunner

Vijay Gondhalekar

Emer Leahy

David Larose

William P. Ross

William Payne Ross

David LaRose

Vijay M Gondhalekar

Heinz Nau

Alan O'Connell

Mark J Day

Taleen G Hanania

Sharon Rae Engel

Milan Chytil

Vadim Alexandrov

Donald Perun

Bavani Shankar

William P Ross

Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A, A, R, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders

A system and method for regulating a proposed transaction between a first party and a seller is provided. The method includes providing a transaction intermediary machine (TIM) on a network that is associated with a transactional limitations database storing in relation to each of a plurality of unique identifiers at least one criterion that has been established by a second party, and concerning one or more transactional limitations imposed by the second party on the first party. A request for approval (RFA) is received from the seller at the TIM having a unique identifier provided by the first party and details concerning the proposed transaction between the first party and the seller. Then, the RFA is compared with the criteria, completion of the proposed transaction is approved and a payment to the seller is also approved, and personal identification information is provided from the TIM to the seller.

System and method for pre-approving, regulating, and executing secure transactions

A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subject's behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is the module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

Method for predicting treatment classes using behavior informatics

A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subjects behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is the module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.

Method for predicting treatment classes using animal behavior informatics

Systems and methods for monitoring behavior informatics

This invention relates to a method for the treatment and prevention of migraine and affective illness by administering a therapeutically effective amount of the valproic acid analog 2-n-propyl-4-hexynoic acid. The compound 2-n-propyl-4-hexynoic acid is an effective anti-migraine and anti-affective illness drug with greatly reduced adverse effects including neurotoxicity and teratogenic potential compared to valproic acid. This invention thus provides an improved method for treating and preventing migraine and affective illness.

Use of valproic acid analog for the treatment and prevention of migraine and affective illness

Growing community of inventors

Pound Ridge, NY, United States of America

Emer Leahy