Universitéde Montreal

Emeline Benoit

Pierre Louis Beaulieu

Jacques Banville

Sasmita Tripathy

Yannick Rose

Michael Dore

Joanne Tan

Hugo Lavoie

Eric Beaulieu

Doris Schuetz

Mukund Ghavre

Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation. The compounds disclosed are of Formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R, R, R, X, X, Xand Xare as defined herein:

Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease

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Montréal, Canada

Emeline Benoit