Sorin Biomedica Cardio S.p.a.

Ela Medical S.a.s.

Tre Esse Progettazione Biomedica S.r.l.

Sorin Biomedica Cardio Crm S.r.l.

Ministero Dell' Universita' E Della Ricera Scientifica E Tecnologica

Emanuela Marcelli

Gianni Plicchi

Guido Gaggini

Bruno Garberoglio

Franco Vallana

Fabrizio Renesto

Luigi Silvestri

Laura Vaccarone

Tonino Bombardini

Laura Cercenelli

Mauro Panfili

An active implantable medical device with biventricular pacing and automatic optimization of pacing configuration. The device collects and analyzes an endocardial acceleration signal (EA), and searches for an optimal pacing configuration based upon a performance index derived from at least one value relating to one and/or the other of the two endocardial acceleration peaks (PEA I, PEA II) over a given heart cycle. Optimization search operates through a scanning of a parameter, e.g., atrio-ventricular delay, and calculation of the surface area underneath the characteristic of the peak amplitude as a function of the scanned parameter (atrioventricular delay).

Active implantable medical device with biventricular pacing and automatic optimization of pacing configuration

The multilumen catheter ( ) is provided at one end with a needle system ( &prime;) formed by two or more single-lumen needles which are provided with respective discharge openings ( ) and which, via their longitudinal lumina ( ), are connected to corresponding lumina ( ) of the catheter for separate release of a tracer fluid for external image diagnostics systems and therapeutic fluids, for example DNA plasmids. The needles may be both straight or both helical or one of these needles may be straight and the other needle may be helical.

Catheter system for performing intramyocardiac therapeutic treatment

Electrodes can generate electrical stimulation pulses at least one first intensity level and at least one second intensity level. The first and second intensity levels are above and below a given stimulation threshold, respectively. The synchronous or asynchronous delivery of second-level pulses enables the conduction of the atrioventricular node to be modulated by electrotonic effect, for example, to reduce ventricular frequency in the event of atrial fibrillation.

Heart stimulation device with electrotonic inhibition

An implantable dual-chamber pacemaker system has a means for automatic beat-to-beat adjustment of the maximum allowable variation (MAV) of the sensed atrial rate (AR) as a function of the sympatho-vagal balance, switching from an atrial tracking mode of operation (e.g., DDD or DDD(R)) to a non atrial tracking mode (e.g., VDI or VDI(R)) when either an arrhythmic tachycardic rate, exceeding the MAV, or a sinus tachycardic rate, exceeding the maximum tracking atrial rate (MTAR), is detected. The pacemaker provides logic means for continuously determining the atrial rate variation (&Dgr;AR) and the MAV. The MAV defines the upper limit for the &Dgr;AR above which tracking is not allowed, discriminating between physiological rate variations and arrhythmic variations. The pacemaker system can return to an atrial tracking mode of operation if the AR remains under a defined rate for a defined number of cycles.

Implantable heart stimulation system with automatic mode switching controlled by sympatho-vagal balance

An implantable defibrillator apparatus having a plurality of defibrillation electrodes which can be applied to the heart muscle in order to apply electric defibrillation shocks thereto, and a defibrillation-controller for selectively applying respective electric defibrillation shocks to the electrodes preferably sequentially in time and in synchronism with the QRS.

Implantable atrial defibrillator apparatus

A device for locating an electrode used in endocardial treatment comprises further electrode means to be positioned inside the heart together with the electrode, the further electrode means being able to adopt a geometrical arrangement defining a system of spatial coordinates. Polarization means are provided for applying respective electrical signals to at least one of the electrode and the further electrode means, as well as detector means connected to the electrode and to the further electrode means for detecting the potential established between the electrode and the further electrode means as a result of the application of the electrical signals. Measuring means sensitive to the potential are capable of determining, on the basis of the potential, the position of the electrode relative to the system of spatial coordinates defined by the further electrode means.

Device for locating endocardial electrodes

An implantable defibrillator apparatus having a plurality of defibrillation electrodes which can be applied to the heart muscle in order to apply electric defibrillation shocks thereto, and defibrillation-control means for selectively applying respective electric defibrillation shocks to the electrodes preferably sequentially in time and in synchronism with the QRS.

Growing community of inventors

Macerata, Italy

Emanuela Marcelli