Genomatica, Inc.

Emanuela E Popova

Andreas W Schirmer

Baolong Zhu

Stephen B Del Cardayre

Zhihao Hu

Behnaz Behrouzian

Donald Eugene Trimbur

Louis G Hom

Haibo Wang

Cindy Chang

Alma Itzel Ramos-Solis

Bernardo Moura Torres Da Costa

Angelica Zabala Bautista

Min Sun Park

Qijun Hu

The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

Omega-hydroxylase-related fusion polypeptide variants with improved properties

The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives

The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

Methods of producing omega-hydroxylated fatty acid derivatives

Growing community of inventors

South San Francisco, CA, United States of America

Emanuela E Popova