Acadia Pharmaceuticals Inc.

Bayer Healthcare LLC

Emanuel Joseph Vizzotti

Stephen Edward Abele

Ravi Tejwani

Renee Nelson

Thomas Dann

Gerard Meisel

Reinhard Walter

Soundarya Vaithianathan

Courtney C Haynes

Debanjan Das

Reginald Bradley

Ravindra W Tejwani

Provided are topical analgesic compositions and methods of preparing topical analgesic compositions comprising a stable nano-encapsulating matrix film. The topical analgesic compositions and methods of preparing topical analgesic compositions may be suited for roll-on applicators. Topical analgesic compositions may include 12 to 16 wt. % menthol; 4 to 8 wt. % camphor; 2 to 15 wt. % film-forming polymer; and 50 to 70 wt. % solvent. To be used in a roll-on applicator, the topical analgesic composition has a viscosity from 800 to 1400 centipoise.

Topical analgesic compositions

Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.

Topical analgesic gel compositions

Provided herein are capsules containing pimavanserin, processes for manufacturing said capsule, and pharmaceutical compositions containing pimavanserin.

Formulations of pimavanserin

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Millburn, NJ, United States of America

Emanuel Joseph Vizzotti