Roche Diagnostics Operations, Inc.

Roche Molecular Systems, Inc.

Roche Diabetes Care, Inc.

Other

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Emad Sarofim

Patrick Griss

Rainer Jaeggi

Claudio Cherubini

Stephan Korner

Irio Giuseppe Calasso

Edwin Oosterbroek

Goran Savatic

Martin Kopp

Andreas Drechsler

Hans-Peter Wahl

Volker Zimmer

Uwe Kraemer

Olivier Elsenhans

Carlo S Effenhauser

Heinz-Michael Hein

Michael Glauser

Roger Iten

Kurt Schildknecht

Nenad Milicevic

Hans List

Steven Nelson Roe

Hans-Peter Haar

David A Hasker

Otto Fuerst

Theo Arnitz

Frank Bergmann

Wilfried Schmid

Thomas Walter

Roland Bernet

Reto Huesser

Kurt Weindel

Ralf Zielenski

Pius Hermann

Rijk Edwin Oosterbroek

Irio Guiseppe Calasso

Daniel Mueller

Urban Georg Schnell

Lotar Schenk

Oliver Gutmann

Heiko Schwertner

Thomas Caratsch

Dave Hasker

Reto Abt

Lukas Birrer

Nicole Gwerder

Geza Burghardt

Jean-Pierre Bolliger

Roger Sandoz

Michael Andreas Heinrich

Wilifried Schmid

Heinz Michael Hein

Michael Kirchgesser

Marko Simic

Daniel Müller

Judith Brand-Meier

Rainer Jäggi

Griss Patrick

Tomas Gruebl

Marco Simic

Michael Heinrich

The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.

Method for processing a biological sample with magnetic particles

According to the present invention, a system (') for processing at least one substrate () containing a dried fluid sample () is provided, the system (&#x2032;) comprising a support () configured to position the substrate (), a laser device () for directing a laser beam () to the substrate (), configured to cut at least one area of the substrate () containing the dried fluid sample () by means of the laser beam (), a container holder (&#x2032;) configured to hold and position a container () for receiving the cut area, the container holder (&#x2032;) being arranged below the substrate (), and an extraction subsystem () for extracting fume and/or dust generated when laser cutting the substrate (), wherein the extraction subsystem () consists of at least two extraction components () sandwiching the substrate () there between. Furthermore, a method for automated processing at least one substrate () containing a dried fluid () sample by means of such a system (&#x2032;) is provided.

Method for processing a dried fluid sample substrate

A method for determining sample container characteristics is presented. The method comprises providing first image data representing a first image of a sample container in a first scenario, wherein in the first scenario, a first illumination condition comprising a sample container background illumination is applied to the sample container; providing second image data representing a second image of the sample container in a second scenario, wherein in the second scenario, a second illumination condition different from the first is applied to the sample container; determining a mask from the first image that indicates a sub-image section of the first image comprising a sample container representation in the first image; determining sub-image data from the second image containing a sample container representation in the second image by applying the mask to the second image; and determining the sample container characteristics from an image data analysis comprising image sub-image data data analysis.

Method for determining characteristics of a sample container in an in-vitro diagnostics system, analyzing device, and in-vitro diagnostics system

A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

Automated system for processing particles

A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.

Device and method for biological sample collection and inspection

System for processing a dried fluid sample substrate and method therefor

A pressure transmission liquid for a cellular analyzer, a system for transferring a liquid cellular sample for analysis by a cellular analyzer, and a method for transferring a liquid cellar sample for analysis are disclosed. The pressure transmission liquid includes an aqueous solution which is isotonic and substantially non-conductive characteristics. The cellular analyzer includes a pipetting module having a pipetting tip, a device for positioning the pipetting module, a sensor for detecting a liquid level of a liquid cellular sample to be analyzed, a pressure transmission liquid, and a pressure transmission liquid conduit connected to the pipetting tip and the pressure transmission liquid reservoir.

Pressure transmission liquid for cellular analyzer, cellular analyzer and method for analyzing a liquid cellular sample

A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.

A system for withdrawing blood from a body part that avoids formation of a drop of blood on the skin surface of the body part after blood removal. The system includes a collecting unit to withdraw blood, a lancing member configured for insertion into the body part and having a capillary to collect blood, and a pressure piece configured to apply pressure to the body part and having an actuator operably connected thereto. The pressure piece is movable relative to a support configured to exert pressure on the body part, and the actuator is configured to reduce the compressive force of the pressure piece after removing an amount of blood, whereby forming a drop of blood on the skin surface of the body part can be avoided.

Method and system for withdrawing blood

An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.

Instrument and method for the automated thermal treatment of liquid samples

A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.

Selective release of sub-group of biological units

An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

Acceleration sensitive indicator

An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.

A system and method for carrying out the withdrawal of body fluid with as little body fluid as possible visible to the user at the end of the process. The present invention provides a pressure piece for exerting pressure on a body part. The pressure piece is moved relative to a support for the body part, and in the final phase of fluid withdrawal, the compressive or resistive force of the pressure piece on the body part is reduced in order to avoid the escape of body fluid from the puncture site. The support results in a defined positioning of the body part that rests against it for the lancing process, whereas the relative movement of the pressure piece enables an additional increase in pressure and thus an improved collection of fluid.

Method and system for withdrawing body fluid

Growing community of inventors

Hagendorn, Switzerland

Emad Sarofim