Abbott Laboratories Corporation

Ema C Olah

Svitlana Y Berezhna

Rene Nieves Alicea

Wenjing Li

Marilou L Coleman

Walter G Stonas

Willie J Cowart

Mahmoud Janbakhsh

Robert Langsner

The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.

Methods and systems for assessing histological stains

The instant disclosure provides spectrophotometric methods for assessing histological stains used in a histology analyzer. The methods find use in various assessments including determinations of the identity of a histological stain, determinations of the quality of a histological stain, etc. Also included are devices and systems for practicing the described methods. The instant disclosure also provides computer readable media containing libraries of reference spectrophotometric characteristics of histological stains useful in assessing a histological stain used in a histology analyzer. Also provided is computer readable media containing instructions that cause a computing device to perform steps for making an assessment of a histological stain.

Spectral differentiation of histological stains

The present disclosure provides methods for the automated control of aspects of slide preparation in an automated slide preparation instrument. Aspects of the methods include automated assessments of reagent amounts, quality and performance as well as automated adjustments of reagents based on such assessments, including the adjustment of reagent amounts, e.g., as present in reagent baths, the adjustment of reagent compositions and the replacement of reagents. Devices and systems useful in performing the described methods are also provided herein.

Assessment and control of reagents in automated slide preparation

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Ventura, CA, United States of America

Ema C Olah