Rootpath Genomics, Inc.

Massachusetts Institute of Technology

Janssen Vaccines & Prevention B.v.

Guangzhou Chengyuan Bioimmunology Technology Co., Ltd.

Ely Blanton Porter

Xi Chen

Darrell J Irvine

Ronald Vogels

Ron Weiss

Mariane Bandeira Melo

Tasuku Kitada

Marijn Van Der Neut Kolfschoten

Provided herein are compositions and methods for assembling nucleic acid sequences encoding T-cell receptors.

Compositions and methods for t-cell receptor gene assembly

Provided herein are compositions and methods to identify a binding element (e.g., peptide, peptoid, or protein) that can be bound by an immunoreceptor (e.g., antibody). The binding element can be provided in a target binding unit comprising two binding elements separated by a spacer such that the two binding elements simultaneously bind to a single molecule comprising an antigen binding domain of an antibody. The present disclosure provides various methods to construct the spacer. The identified binding elements can be further used to manufacture an array which can be used to profile antibodies obtained from a blood sample.

Target binding moiety compositions and methods of use

Provided herein are compositions and methods for high throughout cloning of fused bipartite immunoreceptor polynucleotides encoding cognate pairs of bipartite immunoreceptors. Also provided herein are various applications of the fused bipartite immunoreceptor polynucleotides, expression vectors containing the fused bipartite immunoreceptor polynucleotides, or cells containing the fused bipartite immunoreceptor polynucleotides or expression vectors.

High throughput cloning of paired bipartite immunoreceptor polynucleotides and applications thereof

Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.

Methods and compositions for heterologous repRNA immunizations

Compositions and methods for T-cell receptor gene assembly

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Medford, MA, United States of America

Ely Blanton Porter