Merck Patent Gesellschaft MIT Beschrankter Haftung

Aap Biomaterials Gmbh

Coripharm Medizinprodukte Gmbh & Co. Kg

Smith + Nephew

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Aap Implantate Ag

Aap Inplantate Ag

Aap Biomaterials Gmbh & Co. Kg

Osartis Gmbh

Elvira Dingeldein

Helmut Wahlig

Christoph Sattig

Lydia Heimann

Marco Wolfstadter

Edgar W&uuml;st

Cyrille Gasqueres

Amir Eliezer

Rolf Gericke

Edgar Wüst

Dietrich Heusser

Berthold Nies

Rudolf Gottschlich

Dieter Orth

Rolf Bergmann

Horst Juraszyk

Jurgen Seubert

Gerd Bauer

Dietrich Braun

Werner Rogalski

Richard Kirchlechner

Wighard Strehlow

Frank Witte

Michael Voges

Manfred Wotschokowsky

Ellen Schubert

Georgiana Gasqueres

Hans-Jorg Bauer

Jörg Bauer

Robert Nusko

Gu Moddelmog

Wolfgang Stille

Johannes Rothe

Georg Maier

Amir Elizier

Marco WOLFSTÄDTER

Hubert Clemens Pelikaan

The present invention relates generally to a bio-degradable implant based on magnesium having a reduced corrosion rate and to a method for the production of such an implant. It is a method for treating a surface of a bio-degradable metallic implant comprising the following steps: providing a dispersed system comprising a colloid-dispersed apatite and adding an apatite powder to the dispersed system, subjecting an implant to the dispersed system such that a surface of the implant which is to be treated is immersed in the dispersed system wherein the implant comprises a magnesium based alloy, applying an AC voltage difference between the implant as a first electrode and a second electrode positioned in the dispersed system for generating a plasma electrolytic oxidation on the immersed surface of the implant so that the immersed surface is converted to an oxide film which is at least partially covered by apatites formed by the colloid-dispersed apatite and the apatite powder. The evolution of corrosion induced hydrogen gas evolution is decreased and osseointegration is improved.

PEO coating on Mg screws

The present disclosure relates to a bone cement composed of a hydrophilic component and a hydrophobic component, wherein biodegradable material is deposited in pores of the bone cement via the hydrophilic component.

Bone cement and a method for producing same

The invention relates to a hydroxylapatite material, for the production of which a nanoscale hydroxylapatite paste is subjected to a thermal treatment.

Hydroxylapatite material, and method for the production thereof

The present invention relates generally to a bio-degradable implant based on magnesium having a reduced corrosion rate and to a method for the production of such an implant. It is a a method for treating a surface of a bio-degradable metallic implant comprising the following steps: providing a dispersed system comprising a colloid-dispersed apatite and adding an apatite powder to the dispersed system, subjecting an implant to the dispersed system such that a surface of the implant which is to be treated is immersed in the dispersed system wherein the implant comprises a magnesium based alloy, applying an AC voltage difference between the implant as a first electrode and a second electrode positioned in the dispersed system for generating a plasma electrolytic oxidation on the immersed surface of the implant so that the immersed surface is converted to an oxide film which is at least partially covered by apatites formed by the colloid-dispersed apatite and the apatite powder. The evolution of corrosion induced hydrogen gas evolution is decreased and osseointegration is improved.

The present invention relates generally to an antibacterial coating which is composed of silver, to medical tools and to implants comprising such a coating and to a method as well to an apparatus for the production of such a coating. The medical tools or the dental or orthopaedic implant comprises a metal or metal alloy having a treated surface wherein the treated surface is at least partially converted to an oxide film by plasma electrolytic oxidation using a colloid-dispersed system and wherein the converted surface is partially covered by islands formed by colloid-dispersed silver-particles of the colloid-dispersed system. An Ag&#x2014;TiOcoating shows excellent properties in terms of antibacterial efficacy (even against multi-resistant strains), adhesion and biocompatibility. The life-time of an implant in a human body is increased. The antibacterial coating can be used in the field of traumatology, orthopaedic, osteosynthesis and/or endoprothesis, especially where high infection risk exists.

Osteosynthesis with nano-silver

System of implant components containing active agents, wherein each component is intended to function as an additive for an implant material produced with a powdery or finely granulated starting material and/or active agents and additives. Each component is powdery or finely granulated and includes at least one powdery or finely granulated active agent or additive having a higher dosage than the desired concentration for the application. The components themselves are made of a powdery or finely granulated starting material for the implant material, as well as of the active agent or additive. The active agents can be chemotherapeutical agents, such as antibiotics, whereas the additives can be x-ray contrast materials and/or or additives that alter the physical properties of the starting material, such as its elasticity or viscosity.

Modular implant system containing active substances and method for the production thereof

The invention relates to a process for the production of a collagen implant for wound covering, in which a suspension comprising a telopeptide-containing collagen is produced and a phosphate buffer is added. An areal structure is produced by drying the collagen-containing mixture produced.

Process for the production of collagen material

Blister packaging unit () for at least two components packed in separate individual packages, at least one of which has a pulverulent or granular consistency, which are to be prepared before use with the further packaged component(s) in a mixer or applicator to form a ready-to-use mixture. The individual packages of the components are inserted in correspondingly pre-shaped receptacles () in the blister () of a suitable film or other material and this blister is closed on the side of the open mouth of the receptacles by a cover () of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner. The component(s) having the pulverulent or granular consistency is/are packaged in a respective individual blister pack () shaped at least approximately complementarily to the associated receptacle () in the blister packaging unit, the blister of which has the shape of an elongate trough element () of plastic material tapered at at least one end in the manner of a spout, which trough element(s) comprises a separate tear-off cover () of cardboard, plastic, metal or some other suitable material which may be torn off or opened in some other manner.

Blister pack

A preparation and application device for implant materials consisting of at least one powder or granulate component and one liquid component, which are to be prepared immediately before use, is disclosed. The device comprises a first container which holds the powder or granulate component in a sterile, closed-off manner; and a second container which holds the liquid component in a sterile, closed-off manner and which can be connected to the first container. A mixing shaft which is hollow and located on a mixing mechanism is guided out of the first container is hollow and joins a hand pump for producing negative pressure at its external end. A measuring device which indicates the negative pressure can be connected to the first container and the housing of the hand pump is configured in such a way that it is suitable for use as a handle for moving the mixing shaft.

Preparation and application device for implant materials with hand-operated pump

The invention relates to a preparation and application device for materials which are to be prepared as a paste-like, flowable mass from at least one powder or granulate component and one liquid component, especially bone cement, with an elongated mixing cylinder for receiving the components to be mixed, comprising in one end region a sealable through-opening that can optionally be provided with a discharge unit for the paste-like material to be prepared, and a piston which can be inserted into the other, opposite, open end. The piston is displaceable in the cylinder and seals against the inner wall of the cylinder. The piston is penetrated by an elongated mixing shaft sealed against the piston, and a mixing mechanism is disposed at the cylinder inside-end of the mixing shaft and a handle disposed at the cylinder outside-end of the mixing shaft. The open end of the cylinder located opposite the through-opening and receiving the piston is additionally provided with a removable sealing cap that can be secured on and removed from the cylinder or piston and has a through-opening for the mixing shaft. The piston on the side of the sealing cap has a vacuum fitting adapted for connection to a vacuum source, which can produce a vacuum in the interior of the cylinder through a passageway provided in the piston. The sealing cap includes a through-opening through which the vacuum line that is connected to the vacuum source can be connected to the vacuum fitting in the piston.

Preparation and application device for materials to be prepared as a paste-like flowable mass, especially bone cement

Resorbable bone implant material and method for producing the same

The invention relates to a bone replacement material which comprises one or more polypeptides having the biological action of fibroblast growth factors in a porous matrix. The healing-in properties correspond to those of autologous bone transplantation.

Bone replacement material with FGF

The invention relates to an implant material which is based on a composite material of calcium phosphate ceramic particles and bioabsorbable polymer, in which the proportion of calcium phosphate ceramic particles is at least 50% by weight and the particles are joined to one another by polymer bridges to give a three-dimensional open-pore structure in which the particle surfaces are covered with polymer to the extent of not more than 50%. This implant material is distinguished by particularly favorable growing-in and healing-in properties.

Implant material

New flavanone derivatives of the formula I ##STR1## wherein Ar.sup.1 and Ar.sup.2 are each phenyl which is unsubstituted or monosubstituted to trisubstituted by OH, alkyl, alkoxy, acylamino, halogen, COOalkyl and/or NO.sub.2 and/or substituted by a methylenedioxy group, and the alkyl, alkoxy and acyl groups each have 1-7 C atoms, but wherein the HO group is only in the 6-position if at least one of the radicals Ar.sup.1 and Ar.sup.2 is substituted phenyl, and the phosphoric acid esters thereof and the salts of these compounds display antiallergic effects. Salts of the I-phosphoric acid esters with aminoglycoside antibiotics are outstandingly stable and possess advantageous kinetics of liberation.

Flavanone derivatives

A resorbable porous tricalcium phosphate, in which the pores are sealed with a filler mixture of an antibiotic and a filler, in particular an amino acid, is particularly advantageous for use in the preparation of bone cements.

Tricalcium phosphate for implant materials wherein the pores of the

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Dreieich, Germany

Elvira Dingeldein