Miles Laboratories, Inc.

Miles Inc.

Elva Kurchacova

Meitak Teresa Yip

John W Van Dyke, Jr

Steven C Charlton

Robert T Buckler

Max E Safdy

A layered device suitable for use in the analysis of blood samples which includes a first layer of a matrix material having dispersed therein a complex of copper and a polymer containing multiple pendant carboxyl groups which selectively combines with hemoglobin and bilirubin in fluid communication with a second layer which contains a reagent system which reacts with one or more predetermined analytes in the blood sample to provide a color change.

Multilayered device containing a polymer-copper complex to control

Disclosed is a method for separating biological substances, particularly hemoglobin or bilirubin, from blood plasma or serum which involves contacting the plasma or serum with a water insoluble complex of a polymer containing multiple pendant carboxyl groups and copper.

Use of polymer-copper complex to control interference of biological

The invention involves visual determination of hydrogen peroxide with a multiple oxidative indicator system capable of generating different hues at different concentrations of hydrogen peroxide or at different concentrations of an analyte from which hydrogen peroxide is generated by means of an analyte specific oxidase. A first indicator component of the multiple oxidative indicator system is oxidized from a particular hue to a different hue which is preferably essentially colorless. A second indicator component is oxidized to a hue which is visually distinct from the first indicator component in either of its hues. A third indicator component may also be present which is oxidized to provide a colorimetric response. Each component is oxidized only by hydrogen peroxide and peroxidase. The multiple oxidative indicator system is capable of generating visually distinct hues at different concentrations of hydrogen peroxide and can be used to generate a 'rainbow' of hues when the indicator components are oxidized sequentially.

Multiple oxidative indicator system for visual determination of hydrogen

Disclosed are novel tetrahydro .beta.-carbolines of the formula: ##STR1## wherein R is H, OCH.sub.3 or F; R.sub.1 is H or CH.sub.3 and R.sub.2 is H or COOR.sub.3 where R.sub.3 is H or CH.sub.3. These compounds are useful as antihypertensive agents.

Tetrahydro .beta.-carbolines having antihypertensive activity

Disclosed are novel ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds characterized by the formula: ##STR1## wherein X is H or methoxy and Y is H, Cl or methoxy. These compounds are useful as antihypertensive agents.

Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as

Tetrahydro .beta.-carbolines having anti-hypertensive activity

Aryl-substituted-1,2,4-triazolyl propionic acid compounds, possessing antiinflammatory activity are disclosed. The compounds include: 3-[3-phenyl-1,2,4,(1H)-triazol-5-yl] propionic acid monohydrate; 3-[1-(3-chloro) phenyl and 3-[1-(3,5-dichloro)-phenyl-1,2,4,(1H)-triazol-3-yl] propionic acid; 3-[3-phenyl, 3-[3-(3-bromo)phenyl, 3-[3-(3-chloro)phenyl, and 3-[3-(4-methyl)-phenyl-1,2,4,(1H)-triazol-1-yl] propionic acid.

Growing community of inventors

Elkhart, IN, United States of America

Elva Kurchacova