The Charles Stark Draper Laboratory, Inc.

Else Frohlich

Joseph L Charest

Jeffrey T Borenstein

Christopher M DiBiasio

Kenneth P Vandevoordt

The present disclosure describes systems and methods for mimicking body tissue and the function thereof. The mimicked body tissue can include kidney tissue, the blood brain barrier, and other tissues. In some implementations, the systems described herein are used to test the impact of controlled factors on the tissue. The controlled factors can include flow rates, shear rates, and test chemicals (e.g., therapeutics and toxins). In some implementations, the system and methods are used to test pharmaceutical and biological therapies, characterize healthy or diseased tissue, and observe phenomena of the tissue in vitro.

Microfluidic tissue model

Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit.

Growing community of inventors

Brookline, MA, United States of America

Else Frohlich