University of Louisville Research Foundation, Inc.

Elsa Merit Reyes-Reyes

Paula J Bates

Gerald B Hammond

Bo Xu

Abraham Vaisberg

Francesca R Salipur

Zhuang Jin

Some aspects of the invention include attenuating DNMT1 inhibitor activity in an animal comprising administering an antioxidant. Other aspects of the invention include methods comprising administering a composition comprising a DNMT1 inhibitor and an antioxidant. In some instances in the methods, the animal is undergoing a treatment for cancer. Additional aspects of the invention include compositions comprising a DNMT1 inhibitor and an antioxidant.

Compositions and methods for modulating DNMT1 inhibitor activity

Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.

Compounds, compositions, pharmaceutical compositions, and methods of use

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Prospect, KY, United States of America

Elsa Merit Reyes-Reyes