Medesis Pharma

Centre National De La Recherche Scientifique

Universitè De Montpellier

Elsa Compte

Jean-Claude Maurel

Cyril Lavaud

Yannick Guari

Jaime Francisco Angulo-Mora

Joulia Guari

Jérôme Long

Caroline Bauer

Olivier Gremy

Laurent Miccoli

Lorraine Benigno-Anton

Sophie Grives-Jerphagnon

Patrick Maurel

Jerome Long

The disclosure relates to the treatment and/or prevention of radiation damage by administering a reverse micelle system.

Treatment and prevention of injury due to radiation exposure

The present invention relates to a method for in situ preparation of cyano-bridged coordination polymers as metal nanoparticles within a biocompatible reverse micellar system by mixing at least two reverse micellar systems, each one containing at least one metal salt precursor. The invention also relates to the stabilization of theses nanoparticles by using a biocompatible reverse micellar system. This system takes part of the synthesis as a nanoreactor which comprises at least an acylglycerol, a sterol, lecithin, ethanol and water for the preparation of stable cyano-bridged metal nanoparticles without any use of additional stabilizer agent.

In situ preparation of cyano-bridged metal nanoparticles within a biocompatible reverse micellar system

The present invention relates to reverse-micellar systems comprising at least an active agent, an acylglycerol, a sterol, lecithin, ethanol and water, for use in chelation and/or sequestering of a radionuclide and/or a metal in a patient. The invention also relates to the reverse-micellar systems and to pharmaceutical compositions comprising said reverse-micellar systems.

Use of a reverse-micellar system for delivering chelators of radionuclides and metals

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Montpellier, France

Elsa Compte