Biontech Ag

Consiglio Nazionale Delle Ricerche

Katholieke Universiteit Leuven, Ku Leuven R&d

Aix-marseille Université

Cisi Scrl

Universita′ Degli Studi Di Milano

Fondazione Irccs Istituto Nazionale Dei Tumori

Fondazione Cariplo

Eloise Mastrangelo

Leonardo Manzoni

Pierfausto Seneci

Domenico Delia

Carmelo Drago

Mario Milani De Mayo De Mari

Laura Belvisi

Stefano Maiorana

Martino Bolognesi

Federica Cossu

Daniele Lecis

Paola Maria Chiara Perego

Francesca Vasile

Johan Neyts

Carlo Scolastico

Suzanne Kaptein

Xavier De Lamballerie

Boris Pastorino

Mario De Mayo De Mari Milani

Ilaria Motto

Leonardo Pierpaolo Manzoni

The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.

Homo- and heterodimeric SMAC mimetic compounds as apoptosis inducers

Avermectin and milbemycin compounds, particularly the substance ivermectin, for preparing an antiviral medicament for the treatment, prevention or amelioration of ainfection, such as those caused by YFV (yellow fever virus), DENV (Dengue virus), JEV (Japanese encephalitis virus), TBEV (tick-borne encephalitis virus) or MODV (Modoc virus) are provided. The antiviral compositions of the present invention are suitable for oral administration to a-infected subject or a subject at risk of a infection, such as a human or other mammal.

Avermectins and milbemycins for the treatment, prevention or amelioration of flavivirus infections

The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.

SMAC mimetic compounds as apoptosis inducers

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Milan, Italy

Eloise Mastrangelo