University of California

Vortex Biosciences, Inc.

Elodie Sollier

Dino Di Carlo

Mahdokht Masaeli

Bruce J Richardson

Michael Boyce-Jacino

Michael Lee Kochersperger

James Che

Anna Passernig

Insang Choi

Anatasia Neddersen

Kuo-Wei Huang

Derek Go

Robert F Englert

Microfluidic chips and cartridges and systems that include such chips are disclosed. In some embodiments, the chips include a microfluidic channel disposed in a substrate with the channel comprising at least one expansion region. The channel is configured to generate a vortex within the at least one expansion region in response to fluid through the microfluidic channel to trap cells or particles. The substrate in which the channel is formed may be relatively rigid to resist deformation.

Microfluidic chips and cartridges and systems utilizing microfluidic chips and cartridges

A system and method for the label-free analysis of cells includes a purification device configured to receive a heterogeneous population of cells, the purification device temporarily trapping therein a subpopulation of cells from the heterogeneous population of cells and a cell analysis device positioned downstream of the purification device and configured to measure one or more cellular parameters including cell count, measured cell size, and/or cell morphology. In an alternative embodiment, the subpopulation of cells is analyzed while they are trapped within the purification device.

Apparatus and method for label-free analysis of rare cells from bodily fluids

A particle sorting system includes an inlet and an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, wherein the inlet is connected to an upstream end of the microchannel. A source of different shaped particles is connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet. A plurality of outlets is connected to the microchannel at the downstream expanding region. Fluidic resistors are located in the respective outlets. Different resistances may be used in the outlets to capture enriched fractions of particles having particular particle shape(s).

Devices and methods for shape-based particle separation

Growing community of inventors

Gagny, France

Elodie Sollier