Schering Corporation

Elmer J Mirro

Gregory A Reichard

Jonathan A Pachter

Carol Merrill

Michael W Leach

Eileen A Snyder

Dineshwar Sinha

Mark E Cartwright

Mark R Berardi

Ellen W Evans

Use of an antagonist selected from the group consisting of: (a) antagonists of neurokinin-1 (NK ), neurokinin-2 (NK ) and neurokinin-3 (NK ) receptors, (b) antagonists of NK and NK receptors, (c) antagonists of NK and NK receptors, (d) antagonists of NK and NK receptors, (e) antagonists of NK receptors, and (f) antagonists of NK to treat symptoms and disorders associated with a production and/or secretion of androgen. One aspect of the invention relates to the use of antagonists to suppress production/secretion of androgens in mammals suffering from an androgen-dependent disease, such as benign prostatic hyperplasia and prostatic carcinoma.

Use of neurokinin receptor antagonists to treat androgen-dependent diseases

In one embodiment, the present invention discloses a method and pharmaceutical composition for lowering serum cholesterol in a patient. The method comprises administering to the patient a pharmaceutical composition comprising a therapeutically effective cholesterol lowering amount of an imidazole. An example imidazole useful in the method and composition has the formula:

Imidazoles as cholesterol lowering agents

Growing community of inventors

Wantage, NJ, United States of America

Elmer J Mirro