Abbott Gmbh & Co Kg

Bayer Aktiengesellschaft

Elmar Vilsmaier

Marco Thyes

Peter Klein

Klaus Martin Weber

Markus Grosse

Uwe Petersen

Axel Dalhoff

Gabriele Schmuck

Gunther Milch

Torsten Goerz

The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.

Method for producing biperiden IV

The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo&lsqb;2.2.1.&rsqb;hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo&lsqb;2.2.1&rsqb;hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.

Method for the production of biperiden II

6-Amino-3-azabicyclo&lsqb;3.1.0&rsqb;hexanes of the formula

Special 3-azabicyclo&lsqb;3.1.0&rsqb;hexanes, method for producing and modifying the same, and their use

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Otterbach, Germany

Elmar Vilsmaier