Hoechst Aktiengesellschaft

Elmar Konz

Wilhelm Bartmann

Hansjorg Kruse

Ulrich Lerch

Joachim Kaiser

Rudolf Pistorius

Harry M Geyer

Bernward Scholkens

Gerhard Beck

Franz Hock

Isoquinoline-4-carboxylic acid derivatives of the formula I ##STR1## in which m, n, R.sup.1, R.sup.2, R.sup.3, A and X have the meansings indicated, and physiologically acceptable acid addition salts thereof, a process for their preparation, pharmaceutical formulations based on these compounds and the use thereof as antiarrythmic agents.

Isoquinoline derivatives, pharmaceutical formulations based on these

New isoquinoline derivatives of the general formula ##STR1## and their physiologically acceptable salts, which exert pharmacological actions on the central nervous system and the heart circulation system, a process for the preparation of these compounds, medicaments containing them, and their use as neuroleptic, antihypertonic and antiarrhythmic agents, are described.

Isoquinoline compounds

1-Phenylisoquinoline derivatives of the general formula I ##STR1## and a process for their preparation are described. They act on the central nervous system, in particular as antidepressants.

1-Phenylisoquinoline derivatives, pharmaceutical products containing

What is disclosed are prostacyclin analogs of the general formula I ##STR1## which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI.sub.2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.

Thienyoxy and furyl containing analogs of prostacyclin and their use as

What is disclosed are compounds of the formula ##STR1## which are structurally related to natural prostaglandins and a process for their manufacture. The compounds have valuable pharamacological properties and, therefore, they can be used as medicaments.

Novel prostaglandin derivatives of the .DELTA.2-PGF.sub.2 and

Isoquinolines of the formula ##STR1## in which R.sub.1 is piperidino, piperazino or piperazino N-substituted thereof by alkyl of 1 to 4 carbon atoms, alkylene of 1 to 4 carbon atoms wherein said alkylene is substituted in turn by fluorobenzoyl, or CHO; R.sub.2 is phenyl or phenyl substituted by alkyl of 1 to 4 carbon atoms, halogen, amino or nitro; and R.sub.3 is hydrogen or halogen, a process for their preparation and medicaments containing the isoquinolines, especially the use of said medicaments as antidepressants.

3-Piperidino or apiperazino-1-phenyl or 1-substituted phenyl

Isoquinolines of the formula ##STR1## of which representative compounds are such as 3-N-methylpiperazino-1-phenyl-isoquinoline-4-aldehyde, 3-N-methylpiperazino-1-(2-fluorophenyl)-isoquinoline-4-aldehyde, or 3-N-[3-(4-fluoro-benzoyl)-propyl]-piperazino-1-phenyl-isoquinoline-4-aldeh yde and medicaments containing the isoquinolines which are useful as antidepressants.

Isoquinoline derivatives, processes for their manufacture and their use

Isoquinoline-4-aldehydes of the formula ##STR1## in which X denotes bromine or chlorine, R.sub.1 is phenyl optionally mono- or disubstituted by halogen, hydroxy, nitro, amino, or amino substituted by one or two aliphatic, cycloaliphatic or aromatic hydrocarbon radicals having from 2 to 18 carbon atoms, the nitrogen atom possibly being included in a heterocyclic ring, acyl amino, alkyl or alkoxy each having from 1 to 6 carbon atoms, benzoyloxy, or trifluoromethyl, or is pyridyl or thienyl;

Isoquinoline aldehydes

Isoquinoline derivatives of the formula ##STR1## wherein the substituent is such as chlorine or bromine; R.sub.1 is phenyl etc.; R.sub.2 is hydrogen, halogen etc.; R.sub.3 is e.g. aminoalkyl and their use as medicaments, in particular as antidepressants.

Isoquinoline derivatives

Cyclohexanedione-(1,4)-tetramethyl diketal of the formula ##STR1## is obtained by catalytic hydrogenation of p-benzoquinone tetramethyl diketal in a basic medium, at a temperature of from about -10.degree. to +150.degree. C. The product gives cyclohexanedione-(1,4), on acid hydrolysis, which is a valuable starting product for various syntheses, for example for tetracyanoquinodimethane, a desired compound in the field of semiconductors. Hydroquinone dimethyl ether, which is a valuable intermediate for the dyestuff preparation, is obtained from cyclohexanedione-(1,4)-tetramethyl diketal by catalytic dehydrogenation.

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Bad Soden am Taunus, Germany

Elmar Konz