Basf Aktiengesellschaft

Basf Se Corporation

Evonik Degussa Gmbh

Elmar Heinzle

Oskar Zelder

Stefan Haefner

Corinna Klopprogge

Christoph Wittmann

Bernhard Hauer

Hartwig Schröder

Burkhard Kröger

Janice G Pero

R Rogers Yocum

Andrea Herold

Thomas A Patterson

Hartwig Schroder

Mark K Williams

Patrick Kiefer

Min-Jung Kang

Andreas Tholey

Klaus Hollemeyer

Jens Kroemer

Theron Herman

Hartwig SCHRÖDER

Mark Williams

The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.

Microorganism and process for the preparation of L-methionine

The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine inby way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

[object Object]

A process is described for analyzing enzyme-catalyzed conversions of nonpolymeric substrates to nonpolymeric products with the aid of MALDI-TOF mass spectrometry, preferably in the presence of an internal standard on a specific carrier material.

Method for analyzing enzyme-catalyzed reactions using MALDI-TOF mass spectrometry

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Saarbrücken, Germany

Elmar Heinzle