Massachusetts Institute of Technology

Elly Nedivi

Peter T C So

Christopher Rowlands

Dushan N Wadduwage

Jong Kang Park

Yi Xue

Kalen Berry

Systems and methods herein provide improved, high-throughput multiphoton imaging of thick samples with reduced emission scattering. The systems and methods use structured illumination to modify the excitation light. A reconstruction process can be applied to the resulting images to recover image information free of scattering. The disclosed systems and methods provide high throughput, high signal-to-noise ratio, and high resolution images that are depth selective.

Systems and methods to reduce scattering in temporal focusing multiphoton microscopy

Disclosed herein are CPG15 and CPG15-2 compounds and inhibitors that act as agonists and antagonists of the insulin receptor and insulin-like growth factor receptors, and the use of such compositions for the treatment of insulin and insulin-like growth factor-related diseases.

CPG15 compounds as insulin receptor and insulin-like growth factor receptor agonists

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Newton, MA, United States of America

Elly Nedivi