Molecular Rx, Inc.

Other

Milkhaus Laboratory, Inc.

Cell Med, Inc.

University Patents, Inc.

Signal Coordinating Therapy, Inc.

Molecullar Rx, Inc.

Ellis L Kline

John P McMichael

Daniel H Zimmerman

Walter W McAlhaney

James G Spaulding

In various aspects, the invention relates to immune tolerant glycosidase therapy. The invention provides methods for treating or preventing infectious disease, including chronic viral infections, and highly contagious infectious agents that present an ongoing challenge for the immune system. The compositions and treatment regimens find use with other antiviral or antimicrobial therapies, as well as in conjunction with vaccination to boost effectiveness and/or extend the duration of protective effect. In certain embodiments, the regimen described herein reduces or eliminates the need for administration of other traditional antiviral or antimicrobial therapies. In various embodiments, the invention finds use in immunocompromised patients to boost immune function.

Glycosidase regimen for the treatment of chronic viral infection

The present invention comprises the periodic administration of a solution of neuraminidase to a patient with a neoplasm until the neoplasm has receded. The administration of the solution of neuraminidase can be administered by subcutaneous injection, intramuscular injection, intravenous injection, nasal administration, sublingual administration or transdermal administration. The present invention is effective in treating a wide variety of neoplasms.

Methods and compositions for treating neoplasms

The present invention relates to the diagnosis of multiple sclerosis. More specifically, this invention relates to an assay for detecting antigen(s) associated with multiple sclerosis. The present invention also relates to the generation of hybridomas which produce monoclonal antibodies which are specific for the multiple sclerosis-associated antigens. The present invention's use is in diagnosing multiple sclerosis and in routine follow-up monitoring of multiple sclerosis patients as to disease progression or response to therapy.

Multiple sclerosis associated polypeptide

Methods and compositions are provided for alleviation of disease states involving plaque formation, such as are manifested in Alzheimer's Disease and other amyloid disorders, and arteriosclerotic disease. Methods for the treatment of herpes virus infections by administration of thimerosal are further provided by the invention.

Materials and methods for treatment of plaquing diseases

A method and composition are provided for treatment of disorders involving immunological dysfunction. The invention comprises the administration of a low level of ribonucleotide polymerase protein or a derivative thereof to a human or animal with an immune dysfunction disorder.

Method and composition for the treatment of disorders involving

Method and composition for treatment of disorders involving

Materials and methods for treatment of plaquing disease

A method and composition are provided for treatment of herpes related disorders. The invention comprises the administration of a low level of neuraminidase protein or a derivative thereof. The method is particularly effective in treating herpes related disorders such as shingles, cold sores, herpes lesions in general and chronic fatigue syndrome.

Method and composition for the treatment of a individual infected with

Assay and treatment for demyelinating diseases such as multiple

A method and composition are provided for treatment of herpes virus infections. The invention comprises the administration of a low level of neuraminidase protein or a derivative thereof.

Method for treatment of herpes virus infections

Methods and materials for diagnosis of a multiple sclerosis disease state. Antigenic blood fractions from patients clinically diagnosed for multiple sclerosis are employed to generate heterologous species antibodies. Novel antibody preparations are employed to detect the presence or absence, in a blood sample of a patient to be tested, of immunologically significant components specifically associated with a multiple sclerosis disease state.

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Pendleton, SC, United States of America

Ellis L Kline