Massachusetts Eye and Ear Infirmary

Harvard College

Elliott Kozin

Aaron K Remenschneider

Daniel J Lee

Jennifer Ann Lewis

Michael J McKenna

David B Kolesky

Mark Andrew Skylar-Scott

John Rosowski

Nicole Black

Alexander D Valentine

Heidi Nakajima

Song Cheng

Michael J Mckenna

This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a plurality of spaces between the ribs filled or made with the first material, a different, second material, a combination of the first and a second materials, or a combination of a second material and one or more other different materials. The bilayer graft devices have two components or layers. One component, e.g., the underlay graft device, can include a projection, and the second component, e.g., the overlay graft device, can include an opening that corresponds to the projection (or vice versa) so that the opening and the projection can secure the two layers together in a 'lock and key' manner. This disclosure also features methods of making, using, and implanting the three-dimensional artificial tympanic membrane and bilayer graft devices.

Artificial tympanic membrane devices and uses

The devices described herein are used for holding an undelay graft and an overlay graft in place for repair a tympanic membrane. The devices include a post having a proximal end and a distal end; and first and second arms, each having a proximal end and a distal end. The distal end of the post is flexibly joined to the proximal end of the first arm and to the proximal end of the second arm. When the device is in a deployed configuration, the first arm and the second arm extend substantially perpendicularly from the post; and when the first arm and the second arm are clamped into a constrained configuration, the first arm and the second arm extend substantially parallel to a central axis of the post.

Ear canal grafts

This disclosure features elongated prosthetic devices that can be used to repair, e.g., resurface or occlude, a defect of a semicircular canal, e.g., a superior semicircular canal dehiscence, as well as methods of making and using these devices. For example, the devices can be made using three-dimensional (3D) printing.

Prosthetic devices for semicircular canal defects

Growing community of inventors

Boston, MA, United States of America

Elliott Kozin